Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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gene co-occurrence
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AEH44460.1(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (727 aa)    
Predicted Functional Partners:
AEH44032.1
COGs: COG0248 Exopolyphosphatase; InterPro IPR000119:IPR003695; KEGG: tye:THEYE_A1046 bifunctional 3-dehydroquinate synthase/phosphatase; PFAM: Ppx/GppA phosphatase; histone family protein DNA-binding protein; SMART: histone family protein DNA-binding protein; SPTR: Bifunctional 3-dehydroquinate synthase/phosphatase; IMG reference gene:2505283430; PFAM: Bacterial DNA-binding protein; Ppx/GppA phosphatase family.
 
 
 0.958
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.932
AEH44654.1
MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR004518:IPR011551; KEGG: gsu:GSU1174 nucleoside triphosphate pyrophosphohydrolase; PFAM: MazG nucleotide pyrophosphohydrolase; SPTR: MazG protein; TIGRFAM: MazG family protein; IMG reference gene:2505284073; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein.
  
 
 0.924
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.914
AEH44009.1
COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: ate:Athe_0548 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone domain protein; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; IMG reference gene:2505283407; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
     
 0.902
AEH44241.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 
  0.901
rpsF
Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
  
 
 
 0.887
rplK
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
  
 
 0.883
rplR
Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
  
 
   0.879
rplM
Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.876
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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