Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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AEH44478.1Radical SAM domain protein; COGs: COG0731 Fe-S oxidoreductase; InterPro IPR007197:IPR006638; KEGG: dak:DaAHT2_2249 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Radical SAM domain protein; IMG reference gene:2505283892; PFAM: Radical SAM superfamily. (309 aa)    
Predicted Functional Partners:
pdxA
4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
       0.784
AEH44479.1
DAHP synthetase I/KDSA; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006218; KEGG: afr:AFE_2671 phospho-2-dehydro-3-deoxyheptonate aldolase, putative; PFAM: DAHP synthetase I/KDSA; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase, putative; IMG reference gene:2505283893; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase.
       0.779
obg
GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
 
 
    0.709
pcm
protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
  
    0.600
AEH44971.1
COGs: COG1237 Metal-dependent hydrolase of the beta-lactamase superfamily II; KEGG: nam:NAMH_1777 metal-dependent hydrolase of the beta-lactamase superfamily; SPTR: Putative uncharacterized protein; IMG reference gene:2505284410; PFAM: Metallo-beta-lactamase superfamily.
 
     0.485
AEH44351.1
Ferredoxin (iron-sulfur cluster-binding protein); COGs: COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain; InterPro IPR017896:IPR017900; KEGG: dat:HRM2_42450 ferredoxin (iron-sulfur cluster-binding protein); SPTR: Ferredoxin (Iron-sulfur cluster-binding protein); IMG reference gene:2505283758; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.
 
     0.482
AEH44349.1
Dinitrogenase iron-molybdenum cofactor biosynthesis protein; COGs: COG1433 conserved hypothetical protein; InterPro IPR003731; KEGG: dat:HRM2_46890 hypothetical protein; PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505283756; PFAM: Dinitrogenase iron-molybdenum cofactor.
 
     0.468
AEH44350.1
Cobyrinic acid ac-diamide synthase; COGs: COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain; InterPro IPR017896:IPR017900; KEGG: dol:Dole_0576 cobyrinic acid ac-diamide synthase; SPTR: Cobyrinic acid ac-diamide synthase; IMG reference gene:2505283757; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.
 
     0.457
AEH45224.1
CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR008275:IPR002731:IPR018709; KEGG: tye:THEYE_A0388 (R)-2-hydroxyglutaryl-CoA dehydratase activator-related protein; PFAM: ATPase BadF/BadG/BcrA/BcrD type; Protein of unknown function DUF2229, CoA enzyme activase; SPTR: Putative uncharacterized protein; TIGRFAM: CoA-substrate-specific enzyme activase; IMG reference gene:2505284671; PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component; BadF/BadG/BcrA/BcrD ATPase family; CoA enzyme activase uncharact [...]
       0.415
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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