close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH44519.1ParA protein; COGs: COG1192 ATPase involved in chromosome partitioning; KEGG: bgl:bglu_1g17180 ParA protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505283934; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain. (355 aa)    
Predicted Functional Partners:
AEH44849.1
parB-like partition protein; COGs: COG1475 transcriptional regulator protein; InterPro IPR003115:IPR004437; KEGG: dak:DaAHT2_2007 ParB-like partition protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: Putative uncharacterized protein; TIGRFAM: parB-like partition protein; IMG reference gene:2505284286; PFAM: ParB-like nuclease domain; KorB domain; TIGRFAM: ParB-like partition proteins; Belongs to the ParB family.
 
 
 0.728
AEH43954.1
ParB domain protein nuclease; InterPro IPR003115; KEGG: dol:Dole_2368 nuclease; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: ParB domain protein nuclease; IMG reference gene:2505283351; PFAM: ParB-like nuclease domain.
  
 
 0.688
AEH44680.1
ParB domain protein nuclease; InterPro IPR003115:IPR013838; KEGG: aae:aq_324 hypothetical protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: Putative uncharacterized protein; IMG reference gene:2505284099; PFAM: ParB-like nuclease domain.
  
 
 0.688
AEH45860.1
TonB-dependent receptor; COGs: COG4206 Outer membrane cobalamin receptor protein; InterPro IPR012910:IPR000531; KEGG: glo:Glov_3556 TonB-dependent receptor plug; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; SPTR: TonB-dependent receptor plug; IMG reference gene:2505285345; PFAM: TonB-dependent Receptor Plug Domain; TonB dependent receptor; TIGRFAM: TonB-dependent vitamin B12 receptor.
    
 
 0.584
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.580
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
  
 
 0.525
AEH44537.1
Protein of unknown function DUF1555; InterPro IPR003305:IPR011449:IPR013424; KEGG: mac:MA2808 hypothetical protein; PFAM: protein of unknown function DUF1555; Carbohydrate-binding CenC domain protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505283952; TIGRFAM: PEP-CTERM putative exosortase interaction domain.
   
 
 0.505
AEH44628.1
FG-GAP repeat protein; InterPro IPR013517; KEGG: afu:AF1946 cysteine proteinase, putative; PFAM: FG-GAP repeat protein; SPTR: PKD domain protein; IMG reference gene:2505284046; PFAM: FG-GAP repeat.
   
 
 0.505
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.477
AEH45843.1
COGs: COG0825 Acetyl-CoA carboxylase alpha subunit; InterPro IPR000438:IPR013838:IPR020582; KEGG: dak:DaAHT2_0461 acetyl-CoA carboxylase; PFAM: Acetyl-CoA carboxylase, alpha subunit, conserved region; PRIAM: Acetyl-CoA carboxylase; SPTR: Acetyl-CoA carboxylase; IMG reference gene:2505285325; PFAM: Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit.
  
   0.447
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.