Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH44551.1Two component, sigma54 specific, transcriptional regulator, Fis family; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterProIPR002078:IPR001789:IPR002197:IPR003593:IPR 020441; KEGG: sat:SYN_01093 response regulator; PFAM: sigma-54 factor interaction domain-containing protein; response regulator receiver; helix-turn-helix Fis-type; SMART: response regulator receiver; AAA ATPase; SPTR: Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; IMG reference gene:2505283967; PFAM: Response regulat [...] (458 aa)    
Predicted Functional Partners:
AEH44552.1
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR005467:IPR003661:IPR003594:IPR004358; KEGG: tye:THEYE_A0262 sensory box histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: Signal transduction histidine kinase; IMG reference gene:2505283968; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
 
 
   0.833
AEH44553.1
Hypothetical protein; KEGG: gur:Gura_3412 nucleic acid binding, OB-fold, tRNA/helicase-type; SPTR: Putative uncharacterized protein; IMG reference gene:2505283969.
       0.773
AEH45268.1
COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: sat:SYN_00945 RNA polymerase sigma-54 factor; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: RNA polymerase sigma-54 factor; TIGRFAM: RNA polymerase sigma-54 factor, RpoN; IMG reference gene:2505284717; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54, DNA binding domain; Sigma-54 factor, core binding domain; TIGRFAM: RNA polymerase sigma-54 factor.
 
   
 0.744
cysS
Cysteine synthase; COGs: COG0215 Cysteinyl-tRNA synthetase; InterProIPR001926:IPR015803:IPR001216:IPR005856:IPR 002308; KEGG: sat:SYN_00075 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: cysteine synthase; cysteinyl-tRNA synthetase; IMG reference gene:2505283966; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthases; cysteinyl-tRNA synthetase; cysteine synthase B.
       0.657
AEH44546.1
Hypothetical protein; InterPro IPR011031; KEGG: sse:Ssed_4024 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated; selenocysteine-containing protein; IMG reference gene:2505283962.
       0.651
AEH44547.1
InterPro IPR005797; KEGG: nmr:Nmar_1543 cytochrome b/b6 domain-containing protein; PFAM: Cytochrome b/b6 domain; SPTR: Cytochrome b/b6 domain; IMG reference gene:2505283963.
       0.651
AEH44548.1
Rieske (2Fe-2S) iron-sulfur domain protein; COGs: COG0723 Rieske Fe-S protein; InterPro IPR017941:IPR005805; KEGG: sth:STH3146 plastoquinol--plastocyanin reductase; PFAM: Rieske [2Fe-2S] iron-sulphur domain; SPTR: Plastoquinol--plastocyanin reductase; IMG reference gene:2505283964; PFAM: Rieske [2Fe-2S] domain.
       0.651
AEH44549.1
RNA methyltransferase, TrmA family; COGs: COG2265 SAM-dependent methyltransferase related to tRNA (uracil-5-)-methyltransferase; InterPro IPR002792:IPR010280:IPR001566; KEGG: gem:GM21_2158 RNA methyltransferase, TrmA family; PFAM: (Uracil-5)-methyltransferase; deoxyribonuclease/rho motif-related TRAM; SPTR: RNA methyltransferase, TrmA family; TIGRFAM: RNA methyltransferase, TrmA family; IMG reference gene:2505283965; PFAM: TRAM domain; tRNA (Uracil-5-)-methyltransferase; TIGRFAM: 23S rRNA (uracil-5-)-methyltransferase RumA; Belongs to the class I-like SAM-binding methyltransferase supe [...]
       0.651
AEH44545.1
COGs: COG0226 ABC-type phosphate transport system periplasmic component; InterPro IPR006059:IPR005673; KEGG: dge:Dgeo_0649 periplasmic phosphate binding protein; PFAM: extracellular solute-binding protein family 1; SPTR: ABC-type phosphate transport system, periplasmic component, PstS; TIGRFAM: phosphate ABC transporter, periplasmic phosphate-binding protein; IMG reference gene:2505283961; PFAM: Bacterial extracellular solute-binding protein; TIGRFAM: phosphate ABC transporter, phosphate-binding protein; Belongs to the PstS family.
       0.465
AEH44065.1
COGs: COG1868 Flagellar motor switch protein; InterPro IPR001689:IPR001543; KEGG: sat:SYN_02837 flagellar motor switch protein; PFAM: flagellar motor switch protein FliM; surface presentation of antigens (SPOA) protein; SPTR: Flagellar motor switch protein; TIGRFAM: flagellar motor switch protein FliM; IMG reference gene:2505283463; PFAM: Surface presentation of antigens (SPOA); Flagellar motor switch protein FliM; TIGRFAM: flagellar motor switch protein FliM.
  
  
 0.416
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.