Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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AEH44655.1COGs: COG1423 ATP-dependent DNA ligase homolog of eukaryotic ligase III; InterPro IPR012310:IPR001072; KEGG: tal:Thal_0814 ATP dependent DNA ligase; PFAM: ATP dependent DNA ligase; SPTR: Putative uncharacterized protein; IMG reference gene:2505284074; PFAM: ATP dependent DNA ligase domain; TIGRFAM: RNA ligase, Pab1020 family. (390 aa)    
Predicted Functional Partners:
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
 
     0.833
AEH45910.1
Protein of unknown function UPF0278; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family.
 
     0.790
AEH44657.1
Oligopeptide/dipeptide ABC transporter, ATPase subunit; COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterProIPR003439:IPR013563:IPR003593:IPR017871:IPR 010066; KEGG: tle:Tlet_0198 oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter domain protein; SMART: AAA ATPase; SPTR: Oligopeptide/dipeptide ABC transporter, ATPase subunit; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; IMG reference gene:2505284076; PFAM: ABC transporter; Oligopeptide/dipe [...]
       0.777
AEH44680.1
ParB domain protein nuclease; InterPro IPR003115:IPR013838; KEGG: aae:aq_324 hypothetical protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: Putative uncharacterized protein; IMG reference gene:2505284099; PFAM: ParB-like nuclease domain.
  
     0.749
bpsA
Protein of unknown function DUF43; Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.
  
     0.681
AEH45513.1
Bacterio-opsin activator HTH domain protein; COGs: COG1318 transcriptional regulator protein; KEGG: abi:Aboo_0950 bacterio-opsin activator HTH domain protein; SPTR: Bacterio-opsin activator HTH domain protein; IMG reference gene:2505284976; TIGRFAM: probable regulatory domain.
  
     0.648
AEH44560.1
KEGG: saf:SULAZ_1167 putative lipoprotein; SPTR: Putative lipoprotein; IMG reference gene:2505283976.
  
     0.641
AEH44536.1
Hypothetical protein; KEGG: sat:SYN_01357 putative cytoplasmic protein; SPTR: Hypothetical cytosolic protein; IMG reference gene:2505283951.
  
     0.627
rgy
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
  
     0.614
AEH44968.1
Putative circadian clock protein, KaiC; COGs: COG0467 RecA-superfamily ATPase implicated in signal transduction; InterPro IPR014774:IPR010624; KEGG: aae:aq_204 hypothetical protein; PFAM: Circadian clock protein KaiC central region; SPTR: Putative uncharacterized protein; IMG reference gene:2505284407; PFAM: KaiC; TIGRFAM: KaiC domain protein, AF_0795 family.
  
     0.609
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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