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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa)    
Predicted Functional Partners:
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 0.999
trpC
COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468:IPR013798; KEGG: dak:DaAHT2_0450 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol-phosphate synthase; manually curated; IMG reference gene:2505284432; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 
 0.998
trpB-2
Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.997
trpF
COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: tye:THEYE_A0943 N-(5'phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; IMG reference gene:2505285460; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family.
  
 0.995
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.989
AEH44721.1
Glutamine amidotransferase of anthranilate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR017926:IPR000991:IPR006220:IPR011702:IPR 001317:IPR006221; KEGG: dak:DaAHT2_0448 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; IMG reference gene:2505284146; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
 
  
 0.972
AEH45515.1
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterProIPR019999:IPR005802:IPR018300:IPR001202:IPR 015890:IPR001544; KEGG: dak:DaAHT2_0244 para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding-like; aminotransferase class IV; SPTR: Para-aminobenzoate synthase, component I; TIGRFAM: para-aminobenzoate synthase, subunit I; IMG reference gene:2505284978; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade.
 
  
 0.954
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 
 0.923
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
  
 0.910
AEH44418.1
CDP-diacylglycerol/serine O-phosphatidyltransferase; COGs: COG1183 Phosphatidylserine synthase; InterPro IPR004533:IPR000462; KEGG: dak:DaAHT2_0542 CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: CDP-diacylglycerol/serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; IMG reference gene:2505283831; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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