close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH44726.1Secretion protein HlyD family protein; COGs: COG1566 Multidrug resistance efflux pump; InterPro IPR006143:IPR003997; KEGG: aae:aq_1060 hypothetical protein; PFAM: secretion protein HlyD family protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284151; PFAM: HlyD family secretion protein. (378 aa)    
Predicted Functional Partners:
AEH44728.1
COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: sat:SYN_01010 type I secretion outer membrane protein; PFAM: outer membrane efflux protein; SPTR: Type I secretion outer membrane protein; IMG reference gene:2505284153; PFAM: Outer membrane efflux protein.
 
 
 0.979
AEH44727.1
Drug resistance transporter, EmrB/QacA subfamily; COGs: COG2814 Arabinose efflux permease; InterPro IPR011701:IPR004638; KEGG: ddf:DEFDS_0617 multidrug-efflux transporter MFS family; PFAM: major facilitator superfamily MFS_1; SPTR: Multidrug-efflux transporter, MFS family; TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; IMG reference gene:2505284152; PFAM: Major Facilitator Superfamily; TIGRFAM: drug resistance transporter, EmrB/QacA subfamily.
 
 
 0.970
AEH44022.1
COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: gme:Gmet_3465 outer membrane efflux protein; PFAM: outer membrane efflux protein; SPTR: Outer membrane efflux protein; IMG reference gene:2505283420; PFAM: Outer membrane efflux protein.
 
 
 0.894
AEH45566.1
COGs: COG1538 Outer membrane protein; InterPro IPR010131:IPR003423; KEGG: dal:Dalk_1443 RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; SPTR: RND efflux system, outer membrane lipoprotein, NodT family; TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; IMG reference gene:2505285033; PFAM: Outer membrane efflux protein; TIGRFAM: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family.
 
 
 0.854
AEH44764.1
Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; COGs: COG0836 Mannose-1-phosphate guanylyltransferase; InterPro IPR005835:IPR001538:IPR006375; KEGG: saf:SULAZ_0358 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; PRIAM: Mannose-6-phosphate isomerase; SPTR: Strongly similar to GDP-mannose pyrophosphorylase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; IMG reference gene:2505284191; PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomera [...]
 
  
 0.598
AEH44959.1
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG0446 NAD(FAD)-dependent dehydrogenase; InterPro IPR002355:IPR001763:IPR013027:IPR004099; KEGG: dps:DP2890 NADH oxidase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SMART: Rhodanese domain protein; SPTR: Related to NADH oxidase; IMG reference gene:2505284398; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Rhodanese-like domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain.
  
    0.567
AEH44948.1
Response regulator receiver sensor hybrid histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR020053:IPR001789:IPR003661:IPR003594:IPR 004358:IPR005467; KEGG: cts:Ctha_2310 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SPTR: Putative Histidine kinase; IMG reference gene:2505284387; PFAM: Histidine [...]
  
  
 0.545
secF
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
     
 0.494
AEH44171.1
Formate dehydrogenase accessory protein FdhD; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family.
  
    0.489
AEH44754.1
InterPro IPR011701; KEGG: gbm:Gbem_1224 major facilitator superfamily MFS_1; PFAM: major facilitator superfamily MFS_1; SPTR: Major facilitator superfamily MFS_1; IMG reference gene:2505284181; PFAM: Bacterial protein of unknown function (DUF894).
 
 
 0.477
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.