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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa)    
Predicted Functional Partners:
AEH44750.1
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR003754:IPR003043:IPR006366; KEGG: dal:Dalk_4009 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; IMG reference gene:2505284177; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase.
 0.999
AEH45541.1
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: dak:DaAHT2_0346 porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; IMG reference gene:2505285005; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.995
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.984
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; InterPro IPR005814:IPR004639; KEGG: mta:Moth_1244 glutamate-1-semialdehyde 2,1-aminomutase; PFAM: aminotransferase class-III; SPTR: Glutamate-1-semialdehyde 2,1-aminotransferase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; IMG reference gene:2505283342; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
 
  
 0.923
AEH44062.1
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: tjr:TherJR_1133 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: siroheme synthase; IMG reference gene:2505283460; TIGRFAM: siroheme synthase, N-terminal domain.
  
 0.872
AEH45851.1
COGs: COG1239 Mg-chelatase subunit ChlI; InterPro IPR011704:IPR002035:IPR003593; KEGG: cts:Ctha_2443 magnesium chelatase; PFAM: ATPase associated with various cellular activities AAA_5; von Willebrand factor type A; PRIAM: Magnesium chelatase; SMART: von Willebrand factor type A; AAA ATPase; SPTR: Magnesium chelatase; IMG reference gene:2505285334; PFAM: von Willebrand factor type A domain; AAA domain (dynein-related subfamily); TIGRFAM: magnesium chelatase ATPase subunit D.
  
  
 0.652
AEH44747.1
InterPro IPR013429; KEGG: dol:Dole_3061 FmdB family regulatory protein; PFAM: Putative regulatory protein FmdB; SPTR: Putative regulatory protein, FmdB family; TIGRFAM: regulatory protein, FmdB family; IMG reference gene:2505284174; PFAM: Zinc ribbon domain; TIGRFAM: putative regulatory protein, FmdB family.
       0.646
gmhA
Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
       0.631
AEH44745.1
KEGG: dat:HRM2_35930 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284172.
       0.624
AEH44743.1
Protein of unknown function DUF218; COGs: COG1434 conserved hypothetical protein; InterPro IPR003848; KEGG: ant:Arnit_0792 hypothetical protein; PFAM: protein of unknown function DUF218; SPTR: Putative uncharacterized protein; IMG reference gene:2505284170; PFAM: DUF218 domain.
  
    0.623
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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