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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (219 aa)    
Predicted Functional Partners:
AEH44773.1
COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: sfu:Sfum_0003 putative 6-pyruvoyl tetrahydropterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284200; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: queuosine biosynthesis protein QueD; 6-pyruvoyl tetrahydropterin synthase/QueD family protein.
 
 
 0.998
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 0.994
AEH44009.1
COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144:IPR012833; KEGG: ate:Athe_0548 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone domain protein; SPTR: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; IMG reference gene:2505283407; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
  
 
 0.928
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
 
  
 0.904
AEH44008.1
Hypothetical protein; KEGG: pmo:Pmob_0978 anaerobic ribonucleoside triphosphate reductase; SPTR: Anaerobic ribonucleoside-triphosphate reductase, putative; IMG reference gene:2505283406.
  
 
 0.678
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.568
AEH45224.1
CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR008275:IPR002731:IPR018709; KEGG: tye:THEYE_A0388 (R)-2-hydroxyglutaryl-CoA dehydratase activator-related protein; PFAM: ATPase BadF/BadG/BcrA/BcrD type; Protein of unknown function DUF2229, CoA enzyme activase; SPTR: Putative uncharacterized protein; TIGRFAM: CoA-substrate-specific enzyme activase; IMG reference gene:2505284671; PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component; BadF/BadG/BcrA/BcrD ATPase family; CoA enzyme activase uncharact [...]
       0.519
AEH44241.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.499
rlmH
Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.
   
    0.443
purL
Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...]
     
 0.403
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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