Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH44781.1Protein of unknown function DUF21; COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR000644:IPR002550:IPR005170; KEGG: pmx:PERMA_1603 CBS/transporter-associated domain protein; PFAM: protein of unknown function DUF21; CBS domain containing protein; transporter-associated region; SPTR: CBS/transporter-associated domain protein; IMG reference gene:2505284210; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain. (418 aa)    
Predicted Functional Partners:
AEH44780.1
Protein of unknown function DUF21; COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR000644:IPR002550:IPR005170; KEGG: app:CAP2UW1_1016 protein of unknown function DUF21; PFAM: protein of unknown function DUF21; CBS domain containing protein; transporter-associated region; SMART: CBS domain containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284209; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain.
 
    
0.861
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.502
AEH44782.1
Protein of unknown function UPF0118; COGs: COG0628 permease; InterPro IPR002549; KEGG: pmx:PERMA_1745 membrane protein; PFAM: protein of unknown function UPF0118; SPTR: Membrane protein; IMG reference gene:2505284211; PFAM: Domain of unknown function DUF20.
     
 0.435
AEH44471.1
Amino acid-binding ACT domain protein; InterPro IPR002912; KEGG: mem:Memar_1825 beta-lactamase domain-containing protein; PFAM: amino acid-binding ACT domain protein; SPTR: Beta-lactamase domain protein; IMG reference gene:2505283885; PFAM: Metallo-beta-lactamase superfamily; ACT domain.
  
     0.434
ybeY
Pyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. Belongs to the endoribonuclease YbeY family.
  
    0.411
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
       0.407
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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