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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH44782.1Protein of unknown function UPF0118; COGs: COG0628 permease; InterPro IPR002549; KEGG: pmx:PERMA_1745 membrane protein; PFAM: protein of unknown function UPF0118; SPTR: Membrane protein; IMG reference gene:2505284211; PFAM: Domain of unknown function DUF20. (365 aa)    
Predicted Functional Partners:
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
       0.818
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
       0.551
AEH44780.1
Protein of unknown function DUF21; COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR000644:IPR002550:IPR005170; KEGG: app:CAP2UW1_1016 protein of unknown function DUF21; PFAM: protein of unknown function DUF21; CBS domain containing protein; transporter-associated region; SMART: CBS domain containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284209; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain.
     
 0.440
AEH44781.1
Protein of unknown function DUF21; COGs: COG1253 Hemolysins and related protein containing CBS domains; InterPro IPR000644:IPR002550:IPR005170; KEGG: pmx:PERMA_1603 CBS/transporter-associated domain protein; PFAM: protein of unknown function DUF21; CBS domain containing protein; transporter-associated region; SPTR: CBS/transporter-associated domain protein; IMG reference gene:2505284210; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain.
     
 0.440
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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