Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH44794.1Glutamine amidotransferase class-II; COGs: COG0067 Glutamate synthase domain 1; InterPro IPR000583:IPR017932; KEGG: geo:Geob_3276 glutamine amidotransferase class-II; PFAM: glutamine amidotransferase class-II; SPTR: Glutamine amidotransferase class-II; IMG reference gene:2505284225; PFAM: Glutamine amidotransferases class-II. (402 aa)    
Predicted Functional Partners:
AEH44793.1
COGs: COG0070 Glutamate synthase domain 3; InterPro IPR017441:IPR002489:IPR012061; KEGG: dsa:Desal_1634 glutamate synthase alpha subunit domain protein; PFAM: glutamate synthase alpha subunit domain protein; SPTR: Glutamate synthase alpha subunit domain protein; IMG reference gene:2505284224; PFAM: GXGXG motif.
   0.998
AEH46025.1
Formate dehydrogenase, alpha subunit; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR000759:IPR001041:IPR013027:IPR006963:IPR 006656:IPR006657:IPR018247:IPR017900:IPR006655:IPR017896:I PR006478; KEGG: dak:DaAHT2_0823 formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; ferredoxin; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; SPTR: Formate dehydrogenase, alpha subunit; TIGRFAM: formate dehydrogenase, alpha subunit; manually curated; selenocysteine- [...]
  
 
 0.991
AEH44795.1
COGs: COG0069 Glutamate synthase domain 2; InterPro IPR017900:IPR002932:IPR017896; KEGG: dde:Dde_1814 glutamate synthase (NADPH) GltB2 subunit; PFAM: ferredoxin-dependent glutamate synthase; PRIAM: Glutamate synthase (NADPH); SPTR: Glutamate synthase (NADPH) GltB2 subunit; IMG reference gene:2505284226; PFAM: 4Fe-4S binding domain; Conserved region in glutamate synthase; Belongs to the glutamate synthase family.
 
 
 0.985
AEH44791.1
Protein of unknown function DUF523; COGs: COG1683 conserved hypothetical protein; InterPro IPR007553; KEGG: dps:DP1762 hypothetical protein; PFAM: protein of unknown function DUF523; SPTR: Putative uncharacterized protein; IMG reference gene:2505284222; PFAM: Protein of unknown function (DUF523).
       0.748
purM
Phosphoribosylformylglycinamidine cyclo-ligase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728:IPR010918:IPR004733; KEGG: dak:DaAHT2_1081 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; IMG reference gene:2505284223; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal [...]
       0.748
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
       0.541
purD
Phosphoribosylamine/glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family.
  
  
 0.541
AEH45515.1
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterProIPR019999:IPR005802:IPR018300:IPR001202:IPR 015890:IPR001544; KEGG: dak:DaAHT2_0244 para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding-like; aminotransferase class IV; SPTR: Para-aminobenzoate synthase, component I; TIGRFAM: para-aminobenzoate synthase, subunit I; IMG reference gene:2505284978; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade.
  
  
 0.481
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.422
AEH44241.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
   
 0.406
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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