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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (224 aa)    
Predicted Functional Partners:
AEH44929.1
COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR000097:IPR004808; KEGG: gvi:glr0140 exodeoxyribonuclease III; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Exodeoxyribonuclease III; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; IMG reference gene:2505284368; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth).
 
 0.996
AEH44826.1
Hypothetical protein; KEGG: ddf:DEFDS_0515 cardiolipin synthetase; SPTR: Putative uncharacterized protein; IMG reference gene:2505284259.
       0.803
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.774
AEH45221.1
Asparagine synthase; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232:IPR001962; KEGG: ate:Athe_1202 PP-loop domain protein; PFAM: asparagine synthase; SPTR: PP-loop domain protein; IMG reference gene:2505284668; PFAM: Asparagine synthase; TIGRFAM: TIGR00268 family protein.
 
    0.699
mutM
formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.680
AEH46042.1
InterPro IPR017909:IPR006311; KEGG: dak:DaAHT2_0012 chain A, iron Centre cytochrome c protein; SPTR: Chain A, iron Centre cytochrome c protein; IMG reference gene:2505285531.
  
  
 0.635
AEH44982.1
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR002054:IPR003583:IPR003141:IPR002008:IPR 004013; KEGG: adg:Adeg_1792 DNA-directed DNA polymerase; PFAM: PHP domain protein; SMART: DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; phosphoesterase PHP domain protein; SPTR: DNA-directed DNA polymerase; IMG reference gene:2505284421; PFAM: PHP domain.
     
 0.624
AEH44825.1
MiaB-like tRNA modifying enzyme; COGs: COG0621 2-methylthioadenine synthetase; InterProIPR020612:IPR006638:IPR013848:IPR007197:IPR 005839:IPR006467:IPR002792; KEGG: glo:Glov_2224 MiaB-like tRNA modifying enzyme; PFAM: protein of unknown function UPF0004; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: MiaB-like tRNA modifying enzyme; TIGRFAM: MiaB-like tRNA modifying enzyme; RNA modification enzyme, MiaB family; IMG reference gene:2505284258; PFAM: Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA modifying enzyme; radical [...]
  
  
 0.588
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
       0.560
AEH44824.1
Protein of unknown function DUF933; COGs: COG0012 GTPase probable translation factor; InterPro IPR006073:IPR013029:IPR004396; KEGG: dal:Dalk_1131 protein of unknown function DUF933; PFAM: protein of unknown function DUF933; SPTR: Putative uncharacterized protein; IMG reference gene:2505284257; PFAM: Protein of unknown function (DUF933); TIGRFAM: GTP-binding protein YchF.
       0.547
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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