Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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AEH44847.1Sodium/hydrogen exchanger; COGs: COG4651 Kef-type K+ transport system predicted NAD-binding component; InterPro IPR006153:IPR003148; KEGG: dol:Dole_0855 sodium/hydrogen exchanger; PFAM: sodium/hydrogen exchanger; TrkA-N domain protein; SPTR: Sodium/hydrogen exchanger; IMG reference gene:2505284284; PFAM: TrkA-N domain; Sodium/hydrogen exchanger family; TIGRFAM: transporter, monovalent cation:proton antiporter-2 (CPA2) family. (568 aa)    
Predicted Functional Partners:
nhaA
Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
 
   
 0.562
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
   
 
 0.553
AEH43933.1
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR013099:IPR003148:IPR006037; KEGG: gme:Gmet_0063 TrkA family potassium uptake protein; PFAM: TrkA-N domain protein; Ion transport 2 domain protein; TrkA-C domain protein; SPTR: Potassium uptake protein, TrkA family; IMG reference gene:2505283330; PFAM: TrkA-N domain; Ion channel; TrkA-C domain.
 
   
0.550
secF
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
    0.536
rlpA
Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
       0.533
AEH44806.1
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR006036:IPR003148:IPR006037; KEGG: dba:Dbac_0339 TrkA-N domain protein; PFAM: TrkA-N domain protein; TrkA-C domain protein; SPTR: TrkA-N domain protein; IMG reference gene:2505284239; PFAM: TrkA-N domain; TrkA-C domain.
     
 0.491
AEH45836.1
TrkA-N domain protein; COGs: COG0569 K+ transport systems NAD-binding component; InterPro IPR006036:IPR003148:IPR006037; KEGG: sat:SYN_02618 potassium transporter peripheral membrane component; PFAM: TrkA-N domain protein; TrkA-C domain protein; SPTR: Trk system potassium uptake protein; IMG reference gene:2505285318; PFAM: TrkA-N domain; TrkA-C domain.
     
 0.491
AEH44850.1
Cobyrinic acid a,c-diamide synthase; COGs: COG1192 ATPase involved in chromosome partitioning; KEGG: ppd:Ppro_0583 cobyrinic acid a,c-diamide synthase; SPTR: Chromosome segregation ATPase; IMG reference gene:2505284287; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.
       0.473
AEH44851.1
COGs: COG0212 5-formyltetrahydrofolate cyclo-ligase; InterPro IPR002698; KEGG: tag:Tagg_1069 5-formyltetrahydrofolate cyclo-ligase; PFAM: 5-formyltetrahydrofolate cyclo-ligase; SPTR: 5-formyltetrahydrofolate cyclo-ligase; IMG reference gene:2505284288; PFAM: 5-formyltetrahydrofolate cyclo-ligase family.
       0.469
AEH45985.1
Na+/Ca+ antiporter, CaCA family; COGs: COG0530 Ca2+/Na+ antiporter; InterPro IPR004837:IPR004481; KEGG: tra:Trad_2429 Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region; SPTR: Na+/Ca+ antiporter, CaCA family; TIGRFAM: Na+/Ca+ antiporter, CaCA family; IMG reference gene:2505285474; PFAM: Sodium/calcium exchanger protein; TIGRFAM: K+-dependent Na+/Ca+ exchanger related-protein.
     
 0.467
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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