Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pyrBCOGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006130:IPR002082:IPR006132:IPR006131; KEGG: tjr:TherJR_1833 aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; PRIAM: Aspartate carbamoyltransferase; SPTR: Aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; IMG reference gene:2505284301; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding dom [...] (307 aa)    
Predicted Functional Partners:
carB
COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR005483:IPR005481:IPR005479:IPR005480:IPR 011607:IPR011761:IPR006275; KEGG: dal:Dalk_3481 carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; SPTR: Carbamoyl-phosphate synthase, large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; IMG reference gene:2505283541; PFAM: Carbamoyl-phosphate synthase L cha [...]
 
 0.999
pyrC
Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 0.999
carA
COGs: COG0505 Carbamoylphosphate synthase small subunit; InterProIPR001317:IPR011702:IPR006220:IPR002474:IPR 000991:IPR006274:IPR017926; KEGG: dak:DaAHT2_0900 carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Carbamoyl-phosphate synthase, small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; IMG reference gene:2505284378; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the [...]
 
 0.999
pyrR
Phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
 
 0.996
pyrF
Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
  
 0.950
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.938
pyrD
Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate.
  
  
 0.938
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.935
AEH44589.1
COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR017932:IPR000583:IPR001962:IPR006426; KEGG: tkm:TK90_2515 exosortase 1 system-associated amidotransferase 1; PFAM: asparagine synthase; glutamine amidotransferase class-II; SPTR: Exosortase 1 system-associated amidotransferase 1; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); IMG reference gene:2505284006; PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing).
  
 
 0.912
AEH45594.1
COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962; KEGG: mbu:Mbur_1580 asparagine synthase, glutamine-hydrolyzing; PFAM: asparagine synthase; SPTR: Glutamine amidotransferase class-II:Asparagine synthase; IMG reference gene:2505285061; PFAM: Asparagine synthase.
  
 
 0.912
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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