Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH44894.1rfaE bifunctional protein; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. (400 aa)    
Predicted Functional Partners:
AEH44482.1
PfkB domain protein; COGs: COG2870 ADP-heptose synthase bifunctional sugar kinase/adenylyltransferase; InterPro IPR011611; KEGG: mfa:Mfla_0769 D-beta-D-heptose 1-phosphate adenylyltransferase / D-alpha,beta-D-heptose 7-phosphate 1-kinase; PFAM: PfkB domain protein; SPTR: Bifunctional protein hldE; IMG reference gene:2505283896; PFAM: pfkB family carbohydrate kinase; TIGRFAM: rfaE bifunctional protein, domain I.
 
     0.976
gmhA
Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
   
 0.976
AEH45179.1
Histidinol-phosphate phosphatase family protein; COGs: COG0241 Histidinol phosphatase and related phosphatase; InterPro IPR006543:IPR006549:IPR005834; KEGG: nde:NIDE3031 bifunctional lipopolysaccharide heptosyltransferase II/D, D-heptose 1,7-bisphosphate phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Histidinol-phosphatase; SPTR: Putative uncharacterized protein; TIGRFAM: histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; IMG reference gene:2505284626; PFAM: Polynucleotide kinase 3 phosphatase; TIGRFAM: HAD-superfamil [...]
   
 0.901
AEH44895.1
COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: cth:Cthe_2248 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: Phosphoribosyltransferase; IMG reference gene:2505284334; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein.
  
  
 0.857
AEH44892.1
HAD-superfamily hydrolase, subfamily IA, variant 1; COGs: COG1011 hydrolase (HAD superfamily); InterPro IPR005833:IPR005834:IPR006402:IPR006439; KEGG: ana:alr4095 hypothetical protein; PFAM: Haloacid dehalogenase domain protein hydrolase; SPTR: Alr4095 protein; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; HAD-superfamily hydrolase, subfamily IA, variant 3; IMG reference gene:2505284331; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; haloacid dehalogenase superfamily, subfa [...]
  
    0.790
AEH45178.1
COGs: COG0859 ADP-heptose:LPS heptosyltransferase; InterPro IPR011908:IPR002201; KEGG: tye:THEYE_A0945 lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; SPTR: Lipopolysaccharide heptosyltransferase II; TIGRFAM: lipopolysaccharide heptosyltransferase I; IMG reference gene:2505284625; PFAM: Glycosyltransferase family 9 (heptosyltransferase); TIGRFAM: lipopolysaccharide heptosyltransferase I; lipopolysaccharide heptosyltransferase II.
 
   
 0.789
AEH44893.1
InterPro IPR007197; KEGG: dtu:Dtur_0924 radical SAM domain protein; PFAM: Radical SAM domain protein; SPTR: Radical SAM domain protein; IMG reference gene:2505284332.
       0.778
AEH45180.1
Lipopolysaccharide heptosyltransferase II; COGs: COG0859 ADP-heptose:LPS heptosyltransferase; InterPro IPR011910:IPR002201; KEGG: pna:Pnap_0149 lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; SPTR: ADP-heptose--LPS heptosyltransferase II (Modular protein); TIGRFAM: lipopolysaccharide heptosyltransferase II; IMG reference gene:2505284627; PFAM: Glycosyltransferase family 9 (heptosyltransferase); TIGRFAM: lipopolysaccharide heptosyltransferase II.
 
   
 0.766
AEH45146.1
KpsF/GutQ family protein; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR004800:IPR000644:IPR001347; KEGG: dak:DaAHT2_1635 KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; PRIAM: Arabinose-5-phosphate isomerase; SMART: CBS domain containing protein; SPTR: KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; IMG reference gene:2505284593; PFAM: CBS domain; SIS domain; TIGRFAM: KpsF/GutQ family protein; Belongs to the SIS family. GutQ/KpsF subfamily.
  
  
 0.631
AEH44593.1
Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; COGs: COG2148 Sugar transferase involved in lipopolysaccharide synthesis; InterPro IPR003362:IPR017472:IPR017475; KEGG: hya:HY04AAS1_0831 undecaprenyl-phosphate galactose phosphotransferase, WbaP; PFAM: sugar transferase; PRIAM: Undecaprenyl-phosphate galactose phosphotransferase; SPTR: Undecaprenyl-phosphate galactosephosphotransferase; TIGRFAM: exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Undecaprenyl-phosphate galactose phosphotransferase, WbaP; IMG reference gene:2505284010; PFAM: Bacteri [...]
     
 0.623
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (28%) [HD]