Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH44964.1PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063:IPR012089; KEGG: dal:Dalk_1237 PP-loop domain protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; IMG reference gene:2505284403; PFAM: PP-loop family; Belongs to the TtcA family. (253 aa)    
Predicted Functional Partners:
AEH45221.1
Asparagine synthase; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232:IPR001962; KEGG: ate:Athe_1202 PP-loop domain protein; PFAM: asparagine synthase; SPTR: PP-loop domain protein; IMG reference gene:2505284668; PFAM: Asparagine synthase; TIGRFAM: TIGR00268 family protein.
 
 
    0.567
cysS
Cysteine synthase; COGs: COG0215 Cysteinyl-tRNA synthetase; InterProIPR001926:IPR015803:IPR001216:IPR005856:IPR 002308; KEGG: sat:SYN_00075 cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteinyl-tRNA synthetase; TIGRFAM: cysteine synthase; cysteinyl-tRNA synthetase; IMG reference gene:2505283966; PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthases; cysteinyl-tRNA synthetase; cysteine synthase B.
 
  
 0.549
pth
peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
  
 0.525
hisH
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF; Belongs to the HisA/HisF family.
  
 
 0.505
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.498
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
    0.497
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR004532:IPR002547:IPR005121:IPR005146:IPR 005147; KEGG: sfu:Sfum_0429 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Phenylalanyl-tRNA synthetase beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; IMG reference gene:2505284919; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase [...]
  
  
 0.486
AEH44963.1
Metallophosphoesterase; InterPro IPR004843:IPR004365; KEGG: mif:Metin_0769 metallophosphoesterase; PFAM: metallophosphoesterase; nucleic acid binding OB-fold tRNA/helicase-type; SPTR: Putative uncharacterized protein; IMG reference gene:2505284402; PFAM: Calcineurin-like phosphoesterase.
       0.414
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.