Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEH45030.1Two component, sigma54 specific, transcriptional regulator, Fis family; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterProIPR002078:IPR001789:IPR003593:IPR020441:IPR 002197; KEGG: sfu:Sfum_1934 two component, sigma54 specific, fis family transcriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; response regulator receiver; helix-turn-helix Fis-type; SMART: response regulator receiver; AAA ATPase; SPTR: Two component, sigma54 specific, transcriptional regulator, Fis family; IMG reference gene:250 [...] (453 aa)    
Predicted Functional Partners:
AEH45031.1
COGs: COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation; InterProIPR003660:IPR000014:IPR003661:IPR003594:IPR 004358:IPR013767:IPR017232:IPR005467; KEGG: geo:Geob_2314 PAS/PAC sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; PAS fold domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; PAS domain containing protein; histidine kinase A domain protein; SPTR: PA [...]
 
  0.982
AEH45029.1
COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: tjr:TherJR_2661 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; IMG reference gene:2505284472; PFAM: Methylene-tetrahydrofolate reductase C terminal; Methylenetetrahydrofolate reductase.
       0.782
AEH45032.1
KEGG: dat:HRM2_11180 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284475.
       0.782
AEH45033.1
COGs: COG0778 Nitroreductase; InterPro IPR000415; KEGG: dak:DaAHT2_0557 nitroreductase; PFAM: nitroreductase; SPTR: Nitroreductase; IMG reference gene:2505284476; PFAM: Nitroreductase family.
       0.782
AEH45034.1
NADPH-dependent FMN reductase; COGs: COG0655 Multimeric flavodoxin WrbA; InterPro IPR005025; KEGG: iho:Igni_0620 NADPH-dependent FMN reductase; PFAM: NADPH-dependent FMN reductase; SPTR: NADPH-dependent FMN reductase; IMG reference gene:2505284477; PFAM: NADPH-dependent FMN reductase.
       0.782
speE-2
Spermine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
       0.782
AEH45268.1
COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: sat:SYN_00945 RNA polymerase sigma-54 factor; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: RNA polymerase sigma-54 factor; TIGRFAM: RNA polymerase sigma-54 factor, RpoN; IMG reference gene:2505284717; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54, DNA binding domain; Sigma-54 factor, core binding domain; TIGRFAM: RNA polymerase sigma-54 factor.
 
   
 0.687
AEH44065.1
COGs: COG1868 Flagellar motor switch protein; InterPro IPR001689:IPR001543; KEGG: sat:SYN_02837 flagellar motor switch protein; PFAM: flagellar motor switch protein FliM; surface presentation of antigens (SPOA) protein; SPTR: Flagellar motor switch protein; TIGRFAM: flagellar motor switch protein FliM; IMG reference gene:2505283463; PFAM: Surface presentation of antigens (SPOA); Flagellar motor switch protein FliM; TIGRFAM: flagellar motor switch protein FliM.
  
  
 0.416
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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