Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH45061.1PHP domain protein; COGs: COG1379 conserved hypothetical protein; InterPro IPR004013; KEGG: dtu:Dtur_1268 PHP domain protein; PFAM: PHP domain protein; SPTR: PHP domain protein; IMG reference gene:2505284505; TIGRFAM: TIGR00375 family protein. (425 aa)    
Predicted Functional Partners:
AEH44488.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016:IPR000212; KEGG: drt:Dret_2402 UvrD/REP helicase; PFAM: UvrD/REP helicase; SPTR: UvrD/REP helicase; IMG reference gene:2505283902; PFAM: UvrD/REP helicase.
     0.921
AEH44812.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212:IPR014016:IPR014017; KEGG: nde:NIDE1291 ATP-dependent DNA helicase; PFAM: UvrD/REP helicase; SPTR: UvrD/REP helicase; IMG reference gene:2505284245; PFAM: UvrD/REP helicase.
      0.899
AEH45059.1
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
 
     0.649
AEH45058.1
Thymidylate synthase complementing protein ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
       0.598
AEH45060.1
Protein of unknown function DUF505; COGs: COG1542 conserved hypothetical protein; InterPro IPR007548; KEGG: trq:TRQ2_1791 hypothetical protein; PFAM: protein of unknown function DUF505; SPTR: Putative uncharacterized protein; IMG reference gene:2505284504; PFAM: Protein of unknown function (DUF505).
       0.598
AEH45062.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR004358:IPR013656:IPR013767:IPR005467:IPR000700; KEGG: ppd:Ppro_0904 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; PAC repeat-containing protein; histidine kinase A domain protein; response regulator r [...]
       0.418
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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