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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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gene co-occurrence
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recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)    
Predicted Functional Partners:
AEH45101.1
Uncharacterized protein family UPF0133; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
 
  
 0.987
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
 
 
 
 0.895
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
  
 0.877
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.633
AEH44861.1
Competence/damage-inducible protein CinA; COGs: COG1546 Uncharacterized protein (competence- and mitomycin-induced); InterPro IPR001453:IPR008136:IPR008135; KEGG: dps:DP2957 competence-damage inducible protein (CinA); PFAM: CinA domain protein; molybdopterin binding domain; SPTR: CinA-like protein; TIGRFAM: competence/damage-inducible protein CinA; IMG reference gene:2505284298; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybden [...]
  
  
 0.619
AEH44458.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.571
AEH45098.1
Protein of unknown function DUF329; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
  
    0.571
AEH45105.1
Helix-turn-helix domain protein; InterPro IPR001387:IPR013096; KEGG: amc:MADE_03313 transcriptional regulator, Cro/CI family protein; PFAM: helix-turn-helix domain protein; Cupin 2 conserved barrel domain protein; SMART: helix-turn-helix domain protein; SPTR: Transcriptional regulator, Cro/CI family protein; IMG reference gene:2505284550; PFAM: Helix-turn-helix.
  
    0.570
AEH45104.1
AzlC family protein; COGs: COG1296 branched-chain amino acid permease (azaleucine resistance); InterPro IPR011606; KEGG: ttj:TTHA0235 hypothetical protein; PFAM: AzlC family protein; SPTR: Transporter; IMG reference gene:2505284549; PFAM: AzlC protein; TIGRFAM: 4-azaleucine resistance probable transporter AzlC.
       0.569
AEH45103.1
Branched-chain amino acid transport; InterPro IPR008407; KEGG: mja:MJ1155.1 hypothetical protein; PFAM: branched-chain amino acid transport; SPTR: Uncharacterized protein MJ1155.1; IMG reference gene:2505284548; PFAM: Branched-chain amino acid transport protein (AzlD).
       0.565
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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