Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH45149.1Mg chelatase, subunit ChlI; COGs: COG0606 ATPase with chaperone activity; InterPro IPR004482:IPR003593:IPR000523:IPR001208; KEGG: dal:Dalk_5279 Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; SMART: AAA ATPase; SPTR: Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase, subunit ChlI; IMG reference gene:2505284596; PFAM: Magnesium chelatase, subunit ChlI; TIGRFAM: Mg chelatase-related protein. (503 aa)    
Predicted Functional Partners:
AEH45445.1
DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: gme:Gmet_0890 smf protein; PFAM: SMF family protein; SPTR: SMF protein; TIGRFAM: DNA protecting protein DprA; IMG reference gene:2505284906; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA.
 
 
 0.812
AEH44895.1
COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: cth:Cthe_2248 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: Phosphoribosyltransferase; IMG reference gene:2505284334; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein.
 
  
 0.808
AEH44523.1
Uncharacterized protein family UPF0102; COGs: COG0792 endonuclease distantly related to Holliday junction resolvase; InterPro IPR003509; KEGG: dak:DaAHT2_1166 protein of unknown function UPF0102; PFAM: Uncharacterised protein family UPF0102; SPTR: Putative uncharacterized protein; IMG reference gene:2505283938; PFAM: Uncharacterised protein family UPF0102; TIGRFAM: TIGR00252 family protein; Belongs to the UPF0102 family.
 
    0.781
AEH44051.1
DNA internalization-related competence protein ComEC/Rec2; COGs: COG2333 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR004477:IPR004797; KEGG: nwa:Nwat_0444 DNA internalization-like competence protein ComEC/Rec2; PFAM: ComEC/Rec2-related protein; SPTR: DNA internalization-related competence protein ComEC/Rec2; TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; ComEC/Rec2-related protein; IMG reference gene:2505283449; PFAM: Competence protein; Metallo-beta-lactamase superfamily; TIGRFAM: ComEC/Rec2-related protein; DNA internalization-related competence p [...]
 
  
 0.659
ruvC
Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
  
   
 0.459
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.449
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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