Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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cas2-3CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (96 aa)    
Predicted Functional Partners:
cas1-2
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.979
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.815
AEH45217.1
Tetratricopeptide TPR_1 repeat-containing protein; InterPro IPR019734:IPR001440:IPR013026; KEGG: sfu:Sfum_1354 hypothetical protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; SMART: Tetratricopeptide repeat; SPTR: Putative uncharacterized protein; IMG reference gene:2505284664.
 
     0.808
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
    
0.798
AEH44116.1
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
   
 
 0.786
AEH45220.1
KEGG: nhl:Nhal_2827 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284667; PFAM: Uncharacterized conserved protein (DUF2276); TIGRFAM: CRISPR-associated endoribonuclease Cas6.
 
   
 0.764
AEH45209.1
CRISPR-associated RAMP protein, Cmr4 family; COGs: COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR013410:IPR005537; KEGG: sat:SYN_02249 hypothetical protein; PFAM: protein of unknown function DUF324; SPTR: Hypothetical exported protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; IMG reference gene:2505284656; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr4.
 
     0.688
AEH45207.1
CRISPR-associated RAMP protein, Cmr6 family; COGs: COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR010172:IPR005537; KEGG: sat:SYN_02247 putative cytoplasmic protein; PFAM: protein of unknown function DUF324; SPTR: Hypothetical cytosolic protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr6 family; IMG reference gene:2505284654; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr6.
 
     0.603
AEH45213.1
CRISPR-associated protein, Crm2 family; COGs: COG1353 hydrolase of the HD superfamily (permuted catalytic motifs); InterPro IPR013407; KEGG: sat:SYN_02251 HD superfamily hydrolase; SPTR: Hydrolase of the HD superfamily; TIGRFAM: CRISPR-associated protein, Crm2 family; IMG reference gene:2505284660; PFAM: CRISPR-associated protein; TIGRFAM: CRISPR-associated protein Cas10/Cmr2, subtype III-B.
 
   
 0.598
AEH44107.1
CRISPR-associated RAMP protein, Cmr4 family; COGs: COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR005537:IPR013410; KEGG: pth:PTH_0712 hypothetical protein; PFAM: protein of unknown function DUF324; SPTR: Uncharacterized protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; IMG reference gene:2505283506; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr4.
 
     0.513
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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