Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH45220.1KEGG: nhl:Nhal_2827 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284667; PFAM: Uncharacterized conserved protein (DUF2276); TIGRFAM: CRISPR-associated endoribonuclease Cas6. (314 aa)    
Predicted Functional Partners:
cas2-3
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.764
AEH45213.1
CRISPR-associated protein, Crm2 family; COGs: COG1353 hydrolase of the HD superfamily (permuted catalytic motifs); InterPro IPR013407; KEGG: sat:SYN_02251 HD superfamily hydrolase; SPTR: Hydrolase of the HD superfamily; TIGRFAM: CRISPR-associated protein, Crm2 family; IMG reference gene:2505284660; PFAM: CRISPR-associated protein; TIGRFAM: CRISPR-associated protein Cas10/Cmr2, subtype III-B.
 
  
 0.672
AEH45209.1
CRISPR-associated RAMP protein, Cmr4 family; COGs: COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR013410:IPR005537; KEGG: sat:SYN_02249 hypothetical protein; PFAM: protein of unknown function DUF324; SPTR: Hypothetical exported protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; IMG reference gene:2505284656; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr4.
 
   
 0.625
AEH45221.1
Asparagine synthase; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232:IPR001962; KEGG: ate:Athe_1202 PP-loop domain protein; PFAM: asparagine synthase; SPTR: PP-loop domain protein; IMG reference gene:2505284668; PFAM: Asparagine synthase; TIGRFAM: TIGR00268 family protein.
       0.615
AEH45222.1
Protein of unknown function DUF39; COGs: COG1900 conserved hypothetical protein; InterPro IPR002708; KEGG: dal:Dalk_1368 protein of unknown function DUF39; PFAM: protein of unknown function DUF39; SPTR: Putative uncharacterized protein; IMG reference gene:2505284669; PFAM: Domain of unknown function DUF39.
       0.615
AEH45223.1
COGs: COG0517 FOG: CBS domain; InterPro IPR000644; KEGG: dak:DaAHT2_0620 putative signal transduction protein with CBS domains; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: Putative signal transduction protein with CBS domains; IMG reference gene:2505284670; PFAM: CBS domain.
       0.615
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.592
AEH44107.1
CRISPR-associated RAMP protein, Cmr4 family; COGs: COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR005537:IPR013410; KEGG: pth:PTH_0712 hypothetical protein; PFAM: protein of unknown function DUF324; SPTR: Uncharacterized protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; IMG reference gene:2505283506; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr4.
 
   
 0.557
AEH45207.1
CRISPR-associated RAMP protein, Cmr6 family; COGs: COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR010172:IPR005537; KEGG: sat:SYN_02247 putative cytoplasmic protein; PFAM: protein of unknown function DUF324; SPTR: Hypothetical cytosolic protein; TIGRFAM: CRISPR-associated RAMP protein, Cmr6 family; IMG reference gene:2505284654; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-B/RAMP module RAMP protein Cmr6.
 
   
 0.553
AEH45224.1
CoA-substrate-specific enzyme activase; COGs: COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain); InterPro IPR008275:IPR002731:IPR018709; KEGG: tye:THEYE_A0388 (R)-2-hydroxyglutaryl-CoA dehydratase activator-related protein; PFAM: ATPase BadF/BadG/BcrA/BcrD type; Protein of unknown function DUF2229, CoA enzyme activase; SPTR: Putative uncharacterized protein; TIGRFAM: CoA-substrate-specific enzyme activase; IMG reference gene:2505284671; PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component; BadF/BadG/BcrA/BcrD ATPase family; CoA enzyme activase uncharact [...]
 
     0.543
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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