Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene co-occurrence
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kdsA2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; InterPro IPR006269:IPR006218; KEGG: dps:DP0765 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-8-phosphooctulonate synthase; SPTR: 3-deoxy-8-phosphooctulonate synthase; TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; IMG reference gene:2505284712; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; phospho-2-dehydro-3-deoxyheptonate aldolase. (280 aa)    
Predicted Functional Partners:
AEH45264.1
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; COGs: COG1778 Low specificity phosphatase (HAD superfamily); InterPro IPR010023:IPR006549; KEGG: sfu:Sfum_2073 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; PRIAM: 3-deoxy-manno-octulosonate-8-phosphatase; SPTR: Phosphatase kdsC; TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; IMG reference gene:2505284713; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family.
  
 0.998
AEH45146.1
KpsF/GutQ family protein; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR004800:IPR000644:IPR001347; KEGG: dak:DaAHT2_1635 KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; PRIAM: Arabinose-5-phosphate isomerase; SMART: CBS domain containing protein; SPTR: KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; IMG reference gene:2505284593; PFAM: CBS domain; SIS domain; TIGRFAM: KpsF/GutQ family protein; Belongs to the SIS family. GutQ/KpsF subfamily.
 
 
 0.990
kdsB
3-deoxy-D-manno- octulosonatecytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.849
AEH45267.1
ABC transporter related protein; COGs: COG1137 ABC-type (unclassified) transport system ATPase component; InterPro IPR003593:IPR003439; KEGG: glo:Glov_2167 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: ABC transporter related; IMG reference gene:2505284716; PFAM: ABC transporter; Branched-chain amino acid ATP-binding cassette transporter.
 
  
 0.847
AEH45268.1
COGs: COG1508 DNA-directed RNA polymerase specialized sigma subunit sigma54 homolog; InterPro IPR000394:IPR007046:IPR007634; KEGG: sat:SYN_00945 RNA polymerase sigma-54 factor; PFAM: sigma-54 DNA-binding domain protein; sigma-54 factor core-binding region; sigma-54 factor; SPTR: RNA polymerase sigma-54 factor; TIGRFAM: RNA polymerase sigma-54 factor, RpoN; IMG reference gene:2505284717; PFAM: Sigma-54 factor, Activator interacting domain (AID); Sigma-54, DNA binding domain; Sigma-54 factor, core binding domain; TIGRFAM: RNA polymerase sigma-54 factor.
     
 0.822
lpxK
Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
   
 0.812
AEH45265.1
Protein of unknown function DUF1239; InterPro IPR010664; KEGG: sat:SYN_00948 hypothetical protein; PFAM: protein of unknown function DUF1239; SPTR: Hypothetical membrane protein; IMG reference gene:2505284714; PFAM: Protein of unknown function (DUF1239).
       0.806
AEH45266.1
Lipopolysaccharide transport periplasmic protein LptA; COGs: COG1934 conserved hypothetical protein; InterPro IPR014340:IPR005653; KEGG: gme:Gmet_1281 OstA-like protein; PFAM: OstA family protein; SPTR: OstA-like protein; TIGRFAM: lipopolysaccharide transport periplasmic protein LptA; IMG reference gene:2505284715; PFAM: OstA-like protein; TIGRFAM: lipopolysaccharide transport periplasmic protein LptA.
  
    0.802
AEH45269.1
COGs: COG1544 Ribosome-associated protein Y (PSrp-1); InterPro IPR003489; KEGG: dal:Dalk_1360 sigma 54 modulation protein/ribosomal protein S30EA; PFAM: sigma 54 modulation protein/ribosomal protein S30EA; SPTR: Sigma 54 modulation protein/ribosomal protein S30EA; TIGRFAM: ribosomal subunit interface protein; IMG reference gene:2505284718; PFAM: Sigma 54 modulation protein / S30EA ribosomal protein; TIGRFAM: ribosomal subunit interface protein.
       0.772
lpxC
UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.
 
  
 0.757
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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