Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
kuKu protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (260 aa)    
Predicted Functional Partners:
AEH45292.1
DNA polymerase LigD, ligase domain protein; COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR014146:IPR012310:IPR012309:IPR016059; KEGG: mta:Moth_1488 ATP dependent DNA ligase, central; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; SPTR: ATP dependent DNA ligase, central; TIGRFAM: DNA polymerase LigD, ligase domain protein; IMG reference gene:2505284743; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain.
 
  
 0.962
AEH44153.1
DNA ligase D, 3'-phosphoesterase domain protein; InterPro IPR014144; KEGG: nfa:nfa6770 ATP-dependent DNA ligase; SPTR: Putative ATP-dependent DNA ligase; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; IMG reference gene:2505283554; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
 
  
 0.836
lon-2
ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
       0.778
AEH45862.1
Protein of unknown function DUF72; COGs: COG1801 conserved hypothetical protein; InterPro IPR002763; KEGG: sat:SYN_01732 putative cytoplasmic protein; PFAM: protein of unknown function DUF72; SPTR: Hypothetical cytosolic protein; IMG reference gene:2505285347; PFAM: Protein of unknown function DUF72.
 
    0.471
AEH45289.1
COGs: COG3279 Response regulator of the LytR/AlgR family; InterPro IPR007492; KEGG: pca:Pcar_0056 response regulator; PFAM: LytTr DNA-binding region; SPTR: Response regulator of the LytR/AlgR family; IMG reference gene:2505284739; PFAM: LytTr DNA-binding domain.
       0.406
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.