Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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co-expression
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AEH45292.1DNA polymerase LigD, ligase domain protein; COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR014146:IPR012310:IPR012309:IPR016059; KEGG: mta:Moth_1488 ATP dependent DNA ligase, central; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; SPTR: ATP dependent DNA ligase, central; TIGRFAM: DNA polymerase LigD, ligase domain protein; IMG reference gene:2505284743; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain. (302 aa)    
Predicted Functional Partners:
AEH44153.1
DNA ligase D, 3'-phosphoesterase domain protein; InterPro IPR014144; KEGG: nfa:nfa6770 ATP-dependent DNA ligase; SPTR: Putative ATP-dependent DNA ligase; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain protein; IMG reference gene:2505283554; TIGRFAM: DNA ligase D, 3'-phosphoesterase domain.
 
     0.975
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.962
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.877
AEH44875.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.855
lon-2
ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
       0.778
AEH44982.1
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR002054:IPR003583:IPR003141:IPR002008:IPR 004013; KEGG: adg:Adeg_1792 DNA-directed DNA polymerase; PFAM: PHP domain protein; SMART: DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; phosphoesterase PHP domain protein; SPTR: DNA-directed DNA polymerase; IMG reference gene:2505284421; PFAM: PHP domain.
  
 0.700
AEH45289.1
COGs: COG3279 Response regulator of the LytR/AlgR family; InterPro IPR007492; KEGG: pca:Pcar_0056 response regulator; PFAM: LytTr DNA-binding region; SPTR: Response regulator of the LytR/AlgR family; IMG reference gene:2505284739; PFAM: LytTr DNA-binding domain.
 
     0.484
AEH43947.1
Radical SAM domain protein; COGs: COG1533 DNA repair photolyase; InterPro IPR007197:IPR006638; KEGG: aac:Aaci_2479 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; IMG reference gene:2505283344; PFAM: Radical SAM superfamily.
  
     0.462
AEH45862.1
Protein of unknown function DUF72; COGs: COG1801 conserved hypothetical protein; InterPro IPR002763; KEGG: sat:SYN_01732 putative cytoplasmic protein; PFAM: protein of unknown function DUF72; SPTR: Hypothetical cytosolic protein; IMG reference gene:2505285347; PFAM: Protein of unknown function DUF72.
 
    0.450
AEH45179.1
Histidinol-phosphate phosphatase family protein; COGs: COG0241 Histidinol phosphatase and related phosphatase; InterPro IPR006543:IPR006549:IPR005834; KEGG: nde:NIDE3031 bifunctional lipopolysaccharide heptosyltransferase II/D, D-heptose 1,7-bisphosphate phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Histidinol-phosphatase; SPTR: Putative uncharacterized protein; TIGRFAM: histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; IMG reference gene:2505284626; PFAM: Polynucleotide kinase 3 phosphatase; TIGRFAM: HAD-superfamil [...]
   
 0.443
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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