close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH45359.1Integrase family protein; COGs: COG4974 Site-specific recombinase XerD; InterPro IPR002104; KEGG: dma:DMR_34440 site-specific recombinase; PFAM: integrase family protein; SPTR: Integrase family protein; IMG reference gene:2505284815; PFAM: Phage integrase family; Belongs to the 'phage' integrase family. (396 aa)    
Predicted Functional Partners:
AEH45360.1
KEGG: cyn:Cyan7425_5352 protein of unknown function UPF0175; SPTR: Putative uncharacterized protein; IMG reference gene:2505284816; PFAM: Uncharacterised protein family (UPF0175).
       0.623
AEH45361.1
Hypothetical protein; COGs: COG2405 nucleic acid-binding protein contains PIN domain; KEGG: ter:Tery_4273 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284817; PFAM: Domain of unknown function (DUF3368).
       0.623
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
  
 0.609
AEH44895.1
COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: cth:Cthe_2248 phosphoribosyltransferase; PFAM: phosphoribosyltransferase; SPTR: Phosphoribosyltransferase; IMG reference gene:2505284334; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein.
   
    0.518
AEH45358.1
Ammonium transporter; COGs: COG0004 Ammonia permease; InterPro IPR001905:IPR018047; KEGG: drt:Dret_2267 ammonium transporter; PFAM: ammonium transporter; SPTR: Ammonium transporter; TIGRFAM: ammonium transporter; IMG reference gene:2505284814; PFAM: Ammonium Transporter Family; TIGRFAM: ammonium transporter.
 
     0.460
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
  
 0.451
AEH43939.1
KEGG: dol:Dole_3247 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505283336; PFAM: Protein of unknown function (DUF3343).
  
     0.440
AEH43938.1
Protein of unknown function UPF0031; COGs: COG0063 sugar kinase; InterPro IPR000631:IPR017953; KEGG: tye:THEYE_A1504 hypothetical protein; PFAM: protein of unknown function UPF0031; SPTR: Putative uncharacterized protein; IMG reference gene:2505283335; PFAM: Carbohydrate kinase.
  
     0.408
AEH44813.1
COGs: COG0287 Prephenate dehydrogenase; InterPro IPR004455:IPR003099; KEGG: dal:Dalk_1765 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; NADP oxidoreductase coenzyme F420-dependent; SPTR: Prephenate dehydrogenase; IMG reference gene:2505284246; PFAM: Prephenate dehydrogenase.
  
    0.407
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.