| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEH44262.1 | AEH44364.1 | Thein_0380 | Thein_0482 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: tal:Thal_0562 ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; PRIAM: Galactose-6-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; IMG reference gene:2505283669; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. | 0.936 |
| AEH44262.1 | AEH46013.1 | Thein_0380 | Thein_2165 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: tal:Thal_0562 ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; PRIAM: Galactose-6-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; IMG reference gene:2505283669; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005845:IPR005846:IPR 005843:IPR016066; KEGG: afw:Anae109_0166 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphomannomutase; IMG reference gene:2505285502; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosph [...] | 0.904 |
| AEH44262.1 | prs | Thein_0380 | Thein_1531 | Sugar-phosphate isomerase, RpiB/LacA/LacB family; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: tal:Thal_0562 ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; PRIAM: Galactose-6-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; IMG reference gene:2505283669; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerases, RpiB/LacA/LacB family. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.934 |
| AEH44364.1 | AEH44262.1 | Thein_0482 | Thein_0380 | Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. | Sugar-phosphate isomerase, RpiB/LacA/LacB family; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: tal:Thal_0562 ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; PRIAM: Galactose-6-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; IMG reference gene:2505283669; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerases, RpiB/LacA/LacB family. | 0.936 |
| AEH44364.1 | AEH46003.1 | Thein_0482 | Thein_2155 | Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. | FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1251 NAD(P)H-nitrite reductase; InterPro IPR013027:IPR000103:IPR004099; KEGG: adg:Adeg_1429 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; IMG reference gene:2505285492; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain. | 0.451 |
| AEH44364.1 | AEH46013.1 | Thein_0482 | Thein_2165 | Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. | Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005845:IPR005846:IPR 005843:IPR016066; KEGG: afw:Anae109_0166 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphomannomutase; IMG reference gene:2505285502; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosph [...] | 0.926 |
| AEH44364.1 | prs | Thein_0482 | Thein_1531 | Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.951 |
| AEH45390.1 | ispE | Thein_1529 | Thein_1530 | Domain of unknown function DUF1844; InterPro IPR014995; KEGG: sfu:Sfum_3650 hypothetical protein; PFAM: Domain of unknown function DUF1844; SPTR: Conserved hypothetical cytosolic protein; IMG reference gene:2505284848; PFAM: Domain of unknown function (DUF1844). | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.809 |
| AEH45390.1 | prs | Thein_1529 | Thein_1531 | Domain of unknown function DUF1844; InterPro IPR014995; KEGG: sfu:Sfum_3650 hypothetical protein; PFAM: Domain of unknown function DUF1844; SPTR: Conserved hypothetical cytosolic protein; IMG reference gene:2505284848; PFAM: Domain of unknown function (DUF1844). | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.833 |
| AEH45390.1 | rplY | Thein_1529 | Thein_1532 | Domain of unknown function DUF1844; InterPro IPR014995; KEGG: sfu:Sfum_3650 hypothetical protein; PFAM: Domain of unknown function DUF1844; SPTR: Conserved hypothetical cytosolic protein; IMG reference gene:2505284848; PFAM: Domain of unknown function (DUF1844). | Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. | 0.707 |
| AEH46003.1 | AEH44364.1 | Thein_2155 | Thein_0482 | FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1251 NAD(P)H-nitrite reductase; InterPro IPR013027:IPR000103:IPR004099; KEGG: adg:Adeg_1429 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; IMG reference gene:2505285492; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain. | Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. | 0.451 |
| AEH46003.1 | prs | Thein_2155 | Thein_1531 | FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1251 NAD(P)H-nitrite reductase; InterPro IPR013027:IPR000103:IPR004099; KEGG: adg:Adeg_1429 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; IMG reference gene:2505285492; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.935 |
| AEH46013.1 | AEH44262.1 | Thein_2165 | Thein_0380 | Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005845:IPR005846:IPR 005843:IPR016066; KEGG: afw:Anae109_0166 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphomannomutase; IMG reference gene:2505285502; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosph [...] | Sugar-phosphate isomerase, RpiB/LacA/LacB family; COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: tal:Thal_0562 ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; PRIAM: Galactose-6-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase B; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; IMG reference gene:2505283669; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerases, RpiB/LacA/LacB family. | 0.904 |
| AEH46013.1 | AEH44364.1 | Thein_2165 | Thein_0482 | Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005845:IPR005846:IPR 005843:IPR016066; KEGG: afw:Anae109_0166 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphomannomutase; IMG reference gene:2505285502; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosph [...] | Transketolase domain-containing protein; COGs: COG0021 Transketolase; InterPro IPR005474:IPR005475:IPR005476; KEGG: sfu:Sfum_1302 transketolase; PFAM: Transketolase domain-containing protein; Transketolase central region; SPTR: Transketolase domain protein; IMG reference gene:2505283771; PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain. | 0.926 |
| AEH46013.1 | prs | Thein_2165 | Thein_1531 | Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; COGs: COG1109 Phosphomannomutase; InterProIPR005841:IPR005844:IPR005845:IPR005846:IPR 005843:IPR016066; KEGG: afw:Anae109_0166 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphomannomutase; IMG reference gene:2505285502; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosph [...] | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.916 |
| hisG | prs | Thein_0999 | Thein_1531 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.874 |
| hisG | purF | Thein_0999 | Thein_1038 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.414 |
| ispE | AEH45390.1 | Thein_1530 | Thein_1529 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Domain of unknown function DUF1844; InterPro IPR014995; KEGG: sfu:Sfum_3650 hypothetical protein; PFAM: Domain of unknown function DUF1844; SPTR: Conserved hypothetical cytosolic protein; IMG reference gene:2505284848; PFAM: Domain of unknown function (DUF1844). | 0.809 |
| ispE | prs | Thein_1530 | Thein_1531 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.852 |
| ispE | rplY | Thein_1530 | Thein_1532 | 4-diphosphocytidyl-2C-methyl-D-erythritolkinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. | 0.735 |