Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEH45459.1Regulatory protein MerR; InterPro IPR000551; KEGG: wbm:Wbm0660 transcriptional regulator; PFAM: regulatory protein MerR; SMART: regulatory protein MerR; SPTR: Predicted transcriptional regulator; IMG reference gene:2505284921; PFAM: MerR family regulatory protein. (112 aa)    
Predicted Functional Partners:
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR004532:IPR002547:IPR005121:IPR005146:IPR 005147; KEGG: sfu:Sfum_0429 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Phenylalanyl-tRNA synthetase beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; IMG reference gene:2505284919; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase [...]
     
 0.848
AEH45458.1
COGs: COG0776 Bacterial nucleoid DNA-binding protein; InterPro IPR000119; KEGG: dar:Daro_1327 integration host factor, alpha subunit; PFAM: histone family protein DNA-binding protein; SMART: histone family protein DNA-binding protein; SPTR: Integration host factor subunit alpha 1; IMG reference gene:2505284920; PFAM: Bacterial DNA-binding protein; Belongs to the bacterial histone-like protein family.
  
  
 0.826
rplT
Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
       0.809
pheS
COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterPro IPR004529:IPR006195:IPR004188:IPR002319; KEGG: sat:SYN_01721 phenylalanyl-tRNA synthetase alpha chain; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; SPTR: Phenylalanyl-tRNA synthetase alpha subunit; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; IMG reference gene:2505284918; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacy [...]
     
 0.809
AEH45460.1
COGs: COG0596 hydrolase or acyltransferase (alpha/beta hydrolase superfamily); KEGG: sli:Slin_3239 alpha/beta hydrolase fold protein; SPTR: Alpha/beta hydrolase fold protein; IMG reference gene:2505284922; PFAM: alpha/beta hydrolase fold.
     
 0.768
rpmI
Ribosomal protein L35; InterPro IPR001706:IPR018265:IPR021137; KEGG: cth:Cthe_1224 50S ribosomal protein L35P; PFAM: Ribosomal protein L35; SPTR: 50S ribosomal protein L35; TIGRFAM: ribosomal protein L35; IMG reference gene:2505284916; PFAM: Ribosomal protein L35; TIGRFAM: ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family.
  
    0.745
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 
 0.660
AEH44948.1
Response regulator receiver sensor hybrid histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR020053:IPR001789:IPR003661:IPR003594:IPR 004358:IPR005467; KEGG: cts:Ctha_2310 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SPTR: Putative Histidine kinase; IMG reference gene:2505284387; PFAM: Histidine [...]
   
 
 0.658
infC
Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
     
 0.644
thrS
COGs: COG0441 Threonyl-tRNA synthetase; InterProIPR018158:IPR002320:IPR006195:IPR004095:IPR 012947:IPR002314:IPR004154; KEGG: dak:DaAHT2_1245 threonyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Threonyl/alanyl tRNA synthetase SAD; TGS domain-containing protein; Anticodon-binding domain protein; SPTR: Threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; IMG reference gene:2505284914; PFAM: Anticodon binding domain; Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: threonyl-tRNA synt [...]
       0.639
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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