Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
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gene co-occurrence
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[Homology]
Score
AEH45526.1Metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR003607:IPR006674; KEGG: dvm:DvMF_0995 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Metal dependent phosphohydrolase; IMG reference gene:2505284989; PFAM: HD domain. (422 aa)    
Predicted Functional Partners:
AEH44155.1
Diguanylate cyclase; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: sde:Sde_1595 response regulator receiver domain-containing protein; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein; SPTR: GGDEF domain; TIGRFAM: diguanylate cyclase; IMG reference gene:2505283556; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
 0.956
AEH44846.1
Diguanylate cyclase/phosphodiesterase with GAF sensor; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR000160:IPR001633:IPR003018; KEGG: rfr:Rfer_1825 response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; GAF domain protein; SMART: EAL domain protein; GGDEF domain containing protein; SPTR: Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S); TIGRFAM: diguanylate cyclase; IMG [...]
 
  
 0.908
AEH44760.1
Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR013976; KEGG: ppd:Ppro_3373 diguanylate cyclase; PFAM: GGDEF domain containing protein; Metal-dependent hydrolase HDOD; SMART: GGDEF domain containing protein; SPTR: Diguanylate cyclase; TIGRFAM: diguanylate cyclase; IMG reference gene:2505284187; PFAM: GGDEF domain; HDOD domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
 0.863
AEH44948.1
Response regulator receiver sensor hybrid histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR020053:IPR001789:IPR003661:IPR003594:IPR 004358:IPR005467; KEGG: cts:Ctha_2310 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SPTR: Putative Histidine kinase; IMG reference gene:2505284387; PFAM: Histidine [...]
  
 
 0.786
AEH45062.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR004358:IPR013656:IPR013767:IPR005467:IPR000700; KEGG: ppd:Ppro_0904 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; PAS fold-4 domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; PAC repeat-containing protein; histidine kinase A domain protein; response regulator r [...]
  
 
 0.781
AEH44225.1
Diguanylate cyclase; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: tdn:Suden_1570 diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein; SPTR: Diguanylate cyclase (GGDEF domain); TIGRFAM: diguanylate cyclase; IMG reference gene:2505283631; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
 
 0.780
AEH45183.1
COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR001789; KEGG: dak:DaAHT2_1538 response regulator receiver modulated diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver; SMART: GGDEF domain containing protein; response regulator receiver; SPTR: Response regulator receiver modulated diguanylate cyclase; TIGRFAM: diguanylate cyclase; IMG reference gene:2505284630; PFAM: Response regulator receiver domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
  
 0.756
AEH44401.1
Diguanylate cyclase; COGs: COG2199 FOG: GGDEF domain; InterPro IPR000160; KEGG: dde:Dde_1584 response regulator receiver modulated diguanylate cyclase; PFAM: GGDEF domain containing protein; SMART: GGDEF domain containing protein; SPTR: GGDEF; TIGRFAM: diguanylate cyclase; IMG reference gene:2505283813; PFAM: GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
 
 0.724
AEH44943.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR000014:IPR003594:IPR001789:IPR004358:IPR 013767:IPR005467; KEGG: ddf:DEFDS_0784 hypothetical protein; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; PAS domain containing protein; response regulator receiver; SPTR: Putative uncharacterized protein; TIGRFAM: PAS sensor protein; IMG reference gene:2505284382; PFAM: Histidine kinase-, DNA gy [...]
  
 
 0.703
AEH45246.1
Integral membrane sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003661:IPR003594:IPR001789:IPR003660:IPR 004358:IPR005467; KEGG: dba:Dbac_1409 PAS/PAC sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; SMART: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; SPTR: PAS/PAC sensor hybrid histidine kinase; IMG reference gene:2505284695; PFAM: HAMP do [...]
 
 
 0.663
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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