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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH45527.1Peptidase M24; COGs: COG0006 Xaa-Pro aminopeptidase; InterPro IPR000587:IPR000994; KEGG: dol:Dole_2186 peptidase M24; PFAM: peptidase M24; creatinase; SPTR: Peptidase M24; IMG reference gene:2505284990; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain. (390 aa)    
Predicted Functional Partners:
AEH45528.1
COGs: COG2951 Membrane-bound lytic murein transglycosylase B; KEGG: drt:Dret_1382 MltB; SPTR: MltB; IMG reference gene:2505284991.
       0.810
AEH45529.1
COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: cco:CCC13826_0386 two component transcriptional regulator; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Two component transcriptional regulator, winged helix family; IMG reference gene:2505284992; PFAM: Response regulator receiver domain.
       0.773
AEH44444.1
Peptidase T-like protein; COGs: COG2195 Di- and tripeptidase; InterPro IPR010162:IPR008007:IPR002933:IPR011650; KEGG: dat:HRM2_27370 PepT; PFAM: peptidase dimerisation domain protein; peptidase M20; peptidase M42 family protein; SPTR: PepT; TIGRFAM: peptidase T-like protein; IMG reference gene:2505283857; PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: peptidase T-like protein.
 
 
 0.591
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.538
AEH45586.1
Protein of unknown function DUF399; COGs: COG3016 Uncharacterized iron-regulated protein; InterPro IPR001478:IPR014782:IPR007314; KEGG: pmx:PERMA_0605 putative peptidase M1, membrane alanine aminopeptidase; PFAM: protein of unknown function DUF399; Peptidase M1 membrane alanine aminopeptidase; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; SPTR: Putative peptidase M1, membrane alanine aminopeptidase; IMG reference gene:2505285053; PFAM: Protein of unknown function, DUF399; PDZ domain (Also known as DHR or GLGF).
  
 
 0.533
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
   
 
 0.502
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
   0.493
AEH45526.1
Metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR003607:IPR006674; KEGG: dvm:DvMF_0995 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; SPTR: Metal dependent phosphohydrolase; IMG reference gene:2505284989; PFAM: HD domain.
       0.491
AEH45531.1
KEGG: dba:Dbac_2210 glycosyl transferase, group 1; SPTR: Glycosyl transferase, group 1; IMG reference gene:2505284994.
  
    0.453
cysC
Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
       0.444
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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