Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH45565.1Cytochrome c, class III, conserved region; InterPro IPR002322:IPR011031:IPR020942; KEGG: tye:THEYE_A1056 cytochrome c3 chain A; PFAM: Cytochrome c, class III, conserved region; SPTR: Chain A, Cytochrome C3 From Desulfomicrobium Baculatus; IMG reference gene:2505285032; PFAM: Class III cytochrome C family. (129 aa)    
Predicted Functional Partners:
AEH45564.1
Hypothetical protein; IMG reference gene:2505285031.
       0.773
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.656
AEH44421.1
Heat shock protein 70; COGs: COG0443 Molecular chaperone; InterPro IPR013126:IPR001023:IPR018181; KEGG: dal:Dalk_0767 DnaK-related protein; PFAM: Heat shock protein 70; SPTR: DnaK-related protein; IMG reference gene:2505283834; PFAM: DNA-K related protein; Hsp70 protein.
   
  0.600
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
  0.600
AEH45780.1
Hypothetical protein; KEGG: sat:SYN_01836 MreB-like ATPase involved in cell division; SPTR: Putative uncharacterized protein; IMG reference gene:2505285261.
   
  0.600
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
 0.562
AEH45567.1
Efflux transporter, RND family, MFP subunit; COGs: COG0845 Membrane-fusion protein; InterPro IPR006143; KEGG: dal:Dalk_1444 efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; SPTR: Efflux transporter, RND family, MFP subunit; TIGRFAM: efflux transporter, RND family, MFP subunit; IMG reference gene:2505285034; PFAM: HlyD family secretion protein; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
   
   0.502
clpB
ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.499
AEH45566.1
COGs: COG1538 Outer membrane protein; InterPro IPR010131:IPR003423; KEGG: dal:Dalk_1443 RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; SPTR: RND efflux system, outer membrane lipoprotein, NodT family; TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; IMG reference gene:2505285033; PFAM: Outer membrane efflux protein; TIGRFAM: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family.
       0.491
AEH45568.1
Acriflavin resistance protein; COGs: COG0841 Cation/multidrug efflux pump; InterPro IPR001036; KEGG: dal:Dalk_1445 acriflavin resistance protein; PFAM: acriflavin resistance protein; SPTR: Acriflavin resistance protein; IMG reference gene:2505285035; PFAM: AcrB/AcrD/AcrF family; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
       0.491
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.