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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH45586.1Protein of unknown function DUF399; COGs: COG3016 Uncharacterized iron-regulated protein; InterPro IPR001478:IPR014782:IPR007314; KEGG: pmx:PERMA_0605 putative peptidase M1, membrane alanine aminopeptidase; PFAM: protein of unknown function DUF399; Peptidase M1 membrane alanine aminopeptidase; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; SPTR: Putative peptidase M1, membrane alanine aminopeptidase; IMG reference gene:2505285053; PFAM: Protein of unknown function, DUF399; PDZ domain (Also known as DHR or GLGF). (993 aa)    
Predicted Functional Partners:
AEH45902.1
COGs: COG0405 Gamma-glutamyltransferase; InterPro IPR000101:IPR017441; KEGG: pmx:PERMA_0102 gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; PRIAM: Gamma-glutamyltransferase; SPTR: Gamma-glutamyltransferase; IMG reference gene:2505285389; PFAM: Gamma-glutamyltranspeptidase; TIGRFAM: gamma-glutamyltranspeptidase.
 
  
 0.923
AEH45903.1
Glutamate--cysteine ligase GCS2; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
     
  0.900
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.887
AEH45243.1
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839:IPR004838:IPR001176; KEGG: tye:THEYE_A0342 aspartate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Aspartate aminotransferase; IMG reference gene:2505284692; PFAM: Aminotransferase class I and II.
  
 
 0.851
AEH46060.1
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176:IPR004839:IPR004838; KEGG: dak:DaAHT2_0099 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II; IMG reference gene:2505285551; PFAM: Aminotransferase class I and II.
  
 
 0.851
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterProIPR004532:IPR002547:IPR005121:IPR005146:IPR 005147; KEGG: sfu:Sfum_0429 phenylalanyl-tRNA synthetase, beta subunit; PFAM: B3/4 domain protein; t-RNA-binding domain-containing protein; tRNA synthetase B5; ferredoxin-fold anticodon-binding; SPTR: Phenylalanyl-tRNA synthetase beta subunit; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; IMG reference gene:2505284919; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; TIGRFAM: phenylalanyl-tRNA synthetase [...]
  
 
 0.728
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
 
 0.723
AEH45936.1
Membrane-associated zinc metalloprotease; COGs: COG0750 membrane-associated Zn-dependent protease 1; InterPro IPR008915:IPR001478:IPR004387; KEGG: sfu:Sfum_1785 putative membrane-associated zinc metalloprotease; PFAM: peptidase M50; PDZ/DHR/GLGF domain protein; SMART: PDZ/DHR/GLGF domain protein; SPTR: RseP peptidase. Metallo peptidase. MEROPS family M50B; TIGRFAM: membrane-associated zinc metalloprotease; IMG reference gene:2505285425; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF); TIGRFAM: RIP metalloprotease RseP.
  
  
 0.713
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.711
AEH44985.1
DJ-1 family protein; COGs: COG0693 Putative intracellular protease/amidase; InterPro IPR002818:IPR006287; KEGG: tal:Thal_0984 DJ-1 family protein; PFAM: ThiJ/PfpI domain-containing protein; SPTR: DJ-1 family protein; TIGRFAM: DJ-1 family protein; IMG reference gene:2505284424; PFAM: DJ-1/PfpI family; TIGRFAM: DJ-1 family protein.
  
 
 0.684
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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