| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEH43928.1 | murI | Thein_0043 | Thein_1844 | COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176:IPR004839:IPR005958:IPR004838; KEGG: aba:Acid345_1458 aminotransferase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase; TIGRFAM: tyrosine/nicotianamine aminotransferase; IMG reference gene:2505283325; PFAM: Aminotransferase class I and II; TIGRFAM: tyrosine aminotransferase, eukaryotic; tyrosine/nicotianamine aminotransferases. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.813 |
| AEH45549.1 | murI | Thein_1691 | Thein_1844 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.910 |
| AEH45698.1 | cobD | Thein_1843 | Thein_1840 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.547 |
| AEH45698.1 | cobS | Thein_1843 | Thein_1842 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.547 |
| AEH45698.1 | cobT | Thein_1843 | Thein_1841 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.547 |
| AEH45698.1 | murI | Thein_1843 | Thein_1844 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.778 |
| AEH45900.1 | AEH46044.1 | Thein_2050 | Thein_2196 | COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075:IPR017926; KEGG: dak:DaAHT2_0635 phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase I; IMG reference gene:2505285387; TIGRFAM: phosphoribosylformylglycinamidine synthase I. | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: dal:Dalk_5100 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; IMG reference gene:2505285533; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. | 0.910 |
| AEH45900.1 | murD | Thein_2050 | Thein_0435 | COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075:IPR017926; KEGG: dak:DaAHT2_0635 phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase I; IMG reference gene:2505285387; TIGRFAM: phosphoribosylformylglycinamidine synthase I. | UDP-N-acetylmuramoylalanine/D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.900 |
| AEH45900.1 | murI | Thein_2050 | Thein_1844 | COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075:IPR017926; KEGG: dak:DaAHT2_0635 phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase I; IMG reference gene:2505285387; TIGRFAM: phosphoribosylformylglycinamidine synthase I. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.900 |
| AEH46044.1 | AEH45900.1 | Thein_2196 | Thein_2050 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: dal:Dalk_5100 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; IMG reference gene:2505285533; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. | COGs: COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase glutamine amidotransferase domain; InterPro IPR010075:IPR017926; KEGG: dak:DaAHT2_0635 phosphoribosylformylglycinamidine synthase; PRIAM: Phosphoribosylformylglycinamidine synthase; SPTR: Phosphoribosylformylglycinamidine synthase; TIGRFAM: phosphoribosylformylglycinamidine synthase I; IMG reference gene:2505285387; TIGRFAM: phosphoribosylformylglycinamidine synthase I. | 0.910 |
| AEH46044.1 | murI | Thein_2196 | Thein_1844 | COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: dal:Dalk_5100 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; IMG reference gene:2505285533; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.845 |
| cobD | AEH45698.1 | Thein_1840 | Thein_1843 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | 0.547 |
| cobD | cobS | Thein_1840 | Thein_1842 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.957 |
| cobD | cobT | Thein_1840 | Thein_1841 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.965 |
| cobD | murI | Thein_1840 | Thein_1844 | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.547 |
| cobS | AEH45698.1 | Thein_1842 | Thein_1843 | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | 0.547 |
| cobS | cobD | Thein_1842 | Thein_1840 | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.957 |
| cobS | cobT | Thein_1842 | Thein_1841 | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.985 |
| cobS | murI | Thein_1842 | Thein_1844 | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.567 |
| cobT | AEH45698.1 | Thein_1841 | Thein_1843 | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | 0.547 |