| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEH44458.1 | AEH45700.1 | Thein_0577 | Thein_1845 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | 0.459 |
| AEH44458.1 | cobS | Thein_0577 | Thein_1842 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.453 |
| AEH44458.1 | ribBA | Thein_0577 | Thein_1877 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
| AEH45698.1 | AEH45700.1 | Thein_1843 | Thein_1845 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | 0.542 |
| AEH45698.1 | AEH45701.1 | Thein_1843 | Thein_1846 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Hypothetical protein; InterPro IPR013026; KEGG: dal:Dalk_1963 TPR repeat-containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285172; PFAM: Pilin accessory protein (PilO). | 0.542 |
| AEH45698.1 | cobS | Thein_1843 | Thein_1842 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.547 |
| AEH45698.1 | cobT | Thein_1843 | Thein_1841 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.547 |
| AEH45698.1 | murI | Thein_1843 | Thein_1844 | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.778 |
| AEH45700.1 | AEH44458.1 | Thein_1845 | Thein_0577 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.459 |
| AEH45700.1 | AEH45698.1 | Thein_1845 | Thein_1843 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | 0.542 |
| AEH45700.1 | AEH45701.1 | Thein_1845 | Thein_1846 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | Hypothetical protein; InterPro IPR013026; KEGG: dal:Dalk_1963 TPR repeat-containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285172; PFAM: Pilin accessory protein (PilO). | 0.817 |
| AEH45700.1 | AEH45702.1 | Thein_1845 | Thein_1847 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | Protein of unknown function DUF2202; COGs: COG4902 conserved hypothetical protein; InterPro IPR019243; KEGG: mfs:MFS40622_1425 protein of unknown function DUF2202; PFAM: Protein of unknown function DUF2202; SPTR: Putative uncharacterized protein; IMG reference gene:2505285173; PFAM: Uncharacterized protein domain (DUF2202). | 0.450 |
| AEH45700.1 | cobS | Thein_1845 | Thein_1842 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.468 |
| AEH45700.1 | cobT | Thein_1845 | Thein_1841 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | Nicotinate-nucleotide/dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.468 |
| AEH45700.1 | murI | Thein_1845 | Thein_1844 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.544 |
| AEH45700.1 | ribBA | Thein_1845 | Thein_1877 | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.681 |
| AEH45701.1 | AEH45698.1 | Thein_1846 | Thein_1843 | Hypothetical protein; InterPro IPR013026; KEGG: dal:Dalk_1963 TPR repeat-containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285172; PFAM: Pilin accessory protein (PilO). | Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54. | 0.542 |
| AEH45701.1 | AEH45700.1 | Thein_1846 | Thein_1845 | Hypothetical protein; InterPro IPR013026; KEGG: dal:Dalk_1963 TPR repeat-containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285172; PFAM: Pilin accessory protein (PilO). | COGs: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenase DIM6/NTAB family; InterPro IPR002563; KEGG: tme:Tmel_1752 flavin reductase domain-containing protein; PFAM: flavin reductase domain protein FMN-binding; SPTR: Flavin reductase domain protein, FMN-binding; IMG reference gene:2505285171; PFAM: Flavin reductase like domain. | 0.817 |
| AEH45701.1 | AEH45702.1 | Thein_1846 | Thein_1847 | Hypothetical protein; InterPro IPR013026; KEGG: dal:Dalk_1963 TPR repeat-containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285172; PFAM: Pilin accessory protein (PilO). | Protein of unknown function DUF2202; COGs: COG4902 conserved hypothetical protein; InterPro IPR019243; KEGG: mfs:MFS40622_1425 protein of unknown function DUF2202; PFAM: Protein of unknown function DUF2202; SPTR: Putative uncharacterized protein; IMG reference gene:2505285173; PFAM: Uncharacterized protein domain (DUF2202). | 0.523 |
| AEH45701.1 | murI | Thein_1846 | Thein_1844 | Hypothetical protein; InterPro IPR013026; KEGG: dal:Dalk_1963 TPR repeat-containing protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285172; PFAM: Pilin accessory protein (PilO). | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.542 |