Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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AEH45749.1Glycosyltransferase 28 domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR007235; KEGG: mif:Metin_0813 SMC domain protein; PFAM: Glycosyltransferase 28 domain; SPTR: DNA double-strand break repair Rad50 ATPase; IMG reference gene:2505285225. (757 aa)    
Predicted Functional Partners:
AEH45750.1
Metallophosphoesterase; COGs: COG0420 DNA repair exonuclease; InterPro IPR004843; KEGG: mta:Moth_1789 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Exonuclease SbcD; IMG reference gene:2505285226; PFAM: Calcineurin-like phosphoesterase.
 
 0.999
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.987
AEH45053.1
NERD domain protein; InterPro IPR011528; KEGG: dba:Dbac_0218 NERD domain protein; PFAM: NERD domain protein; SPTR: NERD domain protein; IMG reference gene:2505284496; PFAM: Nuclease-related domain.
 
 0.918
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.876
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.836
AEH44493.1
Hypothetical protein; KEGG: tye:THEYE_A1137 UvrD/REP helicase domain protein, putative; SPTR: UvrD/REP helicase domain protein, putative; IMG reference gene:2505283907; PFAM: Domain of unknown function DUF83.
 
  
 0.802
AEH45662.1
Hypothetical protein; InterPro IPR019734:IPR013026; KEGG: dak:DaAHT2_1194 tetratricopeptide TPR_4; SPTR: Tetratricopeptide TPR_4; IMG reference gene:2505285133.
 
     0.773
AEH45853.1
Hypothetical protein; InterPro IPR018391; KEGG: dal:Dalk_4066 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285336.
  
 
 
 0.769
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
    
   0.769
AEH45947.1
InterPro IPR021136; KEGG: cjr:CJE0040 hypothetical protein; PFAM: Flagellar hook-length control protein-like, C-terminal domain; SPTR: Putative uncharacterized protein; IMG reference gene:2505285436; PFAM: Flagellar hook-length control protein FliK.
  
     0.759
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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