Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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AEH45775.1ATPase, P-type (transporting), HAD superfamily, subfamily IC; COGs: COG0474 Cation transport ATPase; InterProIPR001757:IPR000695:IPR018303:IPR022272:IPR 004014:IPR008250:IPR005834:IPR006068; KEGG: tpe:Tpen_0197 ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; SPTR: ATPase, P-type (Transporting), HAD superfamily, subfamily IC; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; IMG reference gene:2505285255; PFAM: E1-E2 [...] (890 aa)    
Predicted Functional Partners:
AEH45952.1
Aminoglycoside phosphotransferase; COGs: COG2187 conserved hypothetical protein; InterPro IPR002575; KEGG: tye:THEYE_A1962 Uma3; PFAM: aminoglycoside phosphotransferase; SPTR: Uma3; IMG reference gene:2505285441; PFAM: Chromatin associated protein KTI12.
 
    0.588
AEH45774.1
COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: dak:DaAHT2_0726 acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; SPTR: Acetolactate synthase, small subunit; TIGRFAM: acetolactate synthase, small subunit; IMG reference gene:2505285254; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit.
       0.559
AEH45773.1
Acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterProIPR000399:IPR012001:IPR012000:IPR011766:IPR 012846; KEGG: tye:THEYE_A1275 acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; IMG reference gene:2505285253; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-te [...]
  
    0.550
AEH45772.1
KEGG: tye:THEYE_A0863 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285252.
       0.548
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
    0.475
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
       0.475
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
       0.473
AEH43958.1
MgtC/SapB transporter; COGs: COG1285 membrane protein; InterPro IPR003416; KEGG: sfu:Sfum_3054 MgtC/SapB transporter; PFAM: MgtC/SapB transporter; SPTR: MgtC/SapB transporter; IMG reference gene:2505283355; PFAM: MgtC family.
  
 
 0.458
rpsH
Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.
    
   0.431
AEH45878.1
Protein of unknown function UPF0016; COGs: COG2119 membrane protein; InterPro IPR001727; KEGG: amt:Amet_4793 hypothetical protein; PFAM: protein of unknown function UPF0016; SPTR: Putative uncharacterized protein; IMG reference gene:2505285364; PFAM: Uncharacterized protein family UPF0016.
    
 
 0.405
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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