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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa)    
Predicted Functional Partners:
hisH
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF; Belongs to the HisA/HisF family.
  
 0.999
hisB
COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR010916:IPR020565:IPR000807; KEGG: cbh:CLC_1599 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; IMG reference gene:2505284525; PFAM: Imidazoleglycerol-phosphate dehydratase.
  
 0.998
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
 0.996
hisA
COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006063:IPR006062; KEGG: pca:Pcar_2685 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; IMG refe [...]
  
 0.995
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.989
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839:IPR005861:IPR001917; KEGG: dak:DaAHT2_2672 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; IMG reference gene:2505285486; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.985
AEH44710.1
Aminotransferase class I and II; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR004839; KEGG: dat:HRM2_45660 putative histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; PFAM: aminotransferase class I and II; SPTR: Putative histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; IMG reference gene:2505284135; PFAM: Aminotransferase class I and II.
  
 0.862
AEH45838.1
Protein of unknown function UPF0047; COGs: COG0432 conserved hypothetical protein; InterPro IPR001602; KEGG: mpd:MCP_0732 hypothetical protein; PFAM: protein of unknown function UPF0047; SPTR: Putative uncharacterized protein; IMG reference gene:2505285320; PFAM: Uncharacterised protein family UPF0047; TIGRFAM: secondary thiamine-phosphate synthase enzyme.
       0.779
AEH45839.1
Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; COGs: COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I C-terminal domain; InterPro IPR004647; KEGG: dak:DaAHT2_1200 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region; SPTR: Fe-S type hydro-lyases tartrate/fumarate beta region; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; IMG reference gene:2505285321; PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region.
       0.779
AEH45179.1
Histidinol-phosphate phosphatase family protein; COGs: COG0241 Histidinol phosphatase and related phosphatase; InterPro IPR006543:IPR006549:IPR005834; KEGG: nde:NIDE3031 bifunctional lipopolysaccharide heptosyltransferase II/D, D-heptose 1,7-bisphosphate phosphatase; PFAM: Haloacid dehalogenase domain protein hydrolase; PRIAM: Histidinol-phosphatase; SPTR: Putative uncharacterized protein; TIGRFAM: histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; IMG reference gene:2505284626; PFAM: Polynucleotide kinase 3 phosphatase; TIGRFAM: HAD-superfamil [...]
  
  
 0.717
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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