close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH45866.1Cytidyltransferase-related domain protein; COGs: COG1056 Nicotinamide mononucleotide adenylyltransferase; InterPro IPR004820:IPR004821; KEGG: sfu:Sfum_3306 nicotinamide mononucleotide adenylyltransferase; PFAM: cytidylyltransferase; SPTR: Nicotinamide mononucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; IMG reference gene:2505285352; PFAM: Cytidylyltransferase; TIGRFAM: cytidyltransferase-related domain. (186 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.961
cobB
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: rce:RC1_2898 NAD-dependent deacetylase; PFAM: Silent information regulator protein Sir2; SPTR: NAD-dependent deacetylase; IMG reference gene:2505284844; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily.
   
 
  0.955
AEH44986.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
    
 0.936
AEH44861.1
Competence/damage-inducible protein CinA; COGs: COG1546 Uncharacterized protein (competence- and mitomycin-induced); InterPro IPR001453:IPR008136:IPR008135; KEGG: dps:DP2957 competence-damage inducible protein (CinA); PFAM: CinA domain protein; molybdopterin binding domain; SPTR: CinA-like protein; TIGRFAM: competence/damage-inducible protein CinA; IMG reference gene:2505284298; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybden [...]
    
 0.934
nadD
Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
     
 0.914
AEH45660.1
COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR004393:IPR002638; KEGG: dth:DICTH_0588 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; IMG reference gene:2505285131; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family.
     
 0.913
nadK
ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.911
AEH45865.1
Phosphonopyruvate decarboxylase-related protein; COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR004456:IPR019304:IPR006124; KEGG: dak:DaAHT2_2657 phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein; PRIAM: Phosphoglycerate mutase; SPTR: Cofactor-independent phosphoglycerate mutase, archaeal; TIGRFAM: phosphonopyruvate decarboxylase-related protein; IMG reference gene:2505285351; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGR [...]
 
     0.901
AEH45930.1
NAD pyrophosphatase/5'-nucleotidase NadN; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR006179:IPR004843:IPR008334:IPR006420; KEGG: dat:HRM2_09650 UshA; PFAM: 5'-Nucleotidase domain-containing protein; metallophosphoesterase; SPTR: NAD pyrophosphatase/5'-nucleotidase NadN; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN; IMG reference gene:2505285418; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; TIGRFAM: NAD pyrophosphatase/5'-nucleotidase NadN.
     
 0.901
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: medium (58%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.