Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH45866.1Cytidyltransferase-related domain protein; COGs: COG1056 Nicotinamide mononucleotide adenylyltransferase; InterPro IPR004820:IPR004821; KEGG: sfu:Sfum_3306 nicotinamide mononucleotide adenylyltransferase; PFAM: cytidylyltransferase; SPTR: Nicotinamide mononucleotide adenylyltransferase; TIGRFAM: cytidyltransferase-related domain protein; IMG reference gene:2505285352; PFAM: Cytidylyltransferase; TIGRFAM: cytidyltransferase-related domain. (186 aa)    
Predicted Functional Partners:
AEH45865.1
Phosphonopyruvate decarboxylase-related protein; COGs: COG3635 phosphoglycerate mutase AP superfamily; InterPro IPR004456:IPR019304:IPR006124; KEGG: dak:DaAHT2_2657 phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein; PRIAM: Phosphoglycerate mutase; SPTR: Cofactor-independent phosphoglycerate mutase, archaeal; TIGRFAM: phosphonopyruvate decarboxylase-related protein; IMG reference gene:2505285351; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGR [...]
 
     0.902
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
       0.778
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
       0.778
cobB
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: rce:RC1_2898 NAD-dependent deacetylase; PFAM: Silent information regulator protein Sir2; SPTR: NAD-dependent deacetylase; IMG reference gene:2505284844; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily.
   
    0.607
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.586
AEH45909.1
PHP domain protein; COGs: COG0613 metal-dependent phosphoesterase (PHP family); InterPro IPR004013:IPR003141; KEGG: dal:Dalk_3059 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: PHP domain protein; IMG reference gene:2505285396; PFAM: PHP domain.
  
     0.571
AEH44020.1
InterPro IPR010462:IPR013096; KEGG: dal:Dalk_1201 cupin 2 conserved barrel domain protein; PFAM: Cupin 2 conserved barrel domain protein; SPTR: Cupin 2 conserved barrel domain protein; IMG reference gene:2505283418; PFAM: Cupin domain.
  
    0.536
AEH44409.1
Hypothetical protein; KEGG: dal:Dalk_4656 integrin-like repeat-containing protein; SPTR: Integrin-like repeat-containing protein; IMG reference gene:2505283821; PFAM: Curli production assembly/transport component CsgG.
  
     0.467
AEH43939.1
KEGG: dol:Dole_3247 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505283336; PFAM: Protein of unknown function (DUF3343).
  
     0.461
AEH43938.1
Protein of unknown function UPF0031; COGs: COG0063 sugar kinase; InterPro IPR000631:IPR017953; KEGG: tye:THEYE_A1504 hypothetical protein; PFAM: protein of unknown function UPF0031; SPTR: Putative uncharacterized protein; IMG reference gene:2505283335; PFAM: Carbohydrate kinase.
  
     0.449
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.