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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH45870.1GCN5-related N-acetyltransferase; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR013548:IPR000182; KEGG: tye:THEYE_A0040 acetyl-CoA synthetase; PFAM: GCN5-related N-acetyltransferase; Plexin, cytoplasmic RasGAP domain; SPTR: Acetyl-CoA synthetase; IMG reference gene:2505285356; PFAM: Acetyltransferase (GNAT) family. (821 aa)    
Predicted Functional Partners:
AEH45871.1
COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: dps:DP2831 hypothetical protein; PFAM: histone deacetylase superfamily; SPTR: Putative uncharacterized protein; IMG reference gene:2505285357; PFAM: Histone deacetylase domain.
 
     0.857
rnc
Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
  
    0.569
AEH44616.1
N-acylneuraminate cytidylyltransferase; COGs: COG1083 CMP-N-acetylneuraminic acid synthetase; InterPro IPR003329; KEGG: mru:mru_1876 CMP-N-acetylneuraminic acid synthetase NeuA; PFAM: acylneuraminate cytidylyltransferase; PRIAM: N-acylneuraminate cytidylyltransferase; SPTR: CMP-N-acetylneuraminic acid synthetase NeuA; IMG reference gene:2505284033; PFAM: Cytidylyltransferase; Glycosyltransferase family 28 C-terminal domain.
  
  
 0.557
AEH45869.1
Putative transcriptional regulator, ModE family; COGs: COG2005 N-terminal domain of molybdenum-binding protein; InterPro IPR000847; KEGG: tye:THEYE_A0050 molybdenum transport regulatory protein ModE; PFAM: regulatory protein LysR; SPTR: Molybdenum transport regulatory protein ModE; IMG reference gene:2505285355; PFAM: Bacterial regulatory helix-turn-helix protein, lysR family; TIGRFAM: ModE molybdate transport repressor domain.
       0.502
AEH45223.1
COGs: COG0517 FOG: CBS domain; InterPro IPR000644; KEGG: dak:DaAHT2_0620 putative signal transduction protein with CBS domains; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: Putative signal transduction protein with CBS domains; IMG reference gene:2505284670; PFAM: CBS domain.
   
   0.492
AEH44948.1
Response regulator receiver sensor hybrid histidine kinase; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterProIPR020053:IPR001789:IPR003661:IPR003594:IPR 004358:IPR005467; KEGG: cts:Ctha_2310 PAS/PAC sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; response regulator receiver; histidine kinase A domain protein; SPTR: Putative Histidine kinase; IMG reference gene:2505284387; PFAM: Histidine [...]
  
 
 0.488
cobB
Silent information regulator protein Sir2; COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; InterPro IPR003000; KEGG: rce:RC1_2898 NAD-dependent deacetylase; PFAM: Silent information regulator protein Sir2; SPTR: NAD-dependent deacetylase; IMG reference gene:2505284844; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily.
     
 0.478
nnrE
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
  
    0.469
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
  
  
 0.468
AEH44038.1
acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
  
 0.467
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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