Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEH45910.1Protein of unknown function UPF0278; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family. (199 aa)    
Predicted Functional Partners:
AEH44655.1
COGs: COG1423 ATP-dependent DNA ligase homolog of eukaryotic ligase III; InterPro IPR012310:IPR001072; KEGG: tal:Thal_0814 ATP dependent DNA ligase; PFAM: ATP dependent DNA ligase; SPTR: Putative uncharacterized protein; IMG reference gene:2505284074; PFAM: ATP dependent DNA ligase domain; TIGRFAM: RNA ligase, Pab1020 family.
 
     0.790
AEH44680.1
ParB domain protein nuclease; InterPro IPR003115:IPR013838; KEGG: aae:aq_324 hypothetical protein; PFAM: ParB domain protein nuclease; SMART: ParB domain protein nuclease; SPTR: Putative uncharacterized protein; IMG reference gene:2505284099; PFAM: ParB-like nuclease domain.
  
     0.692
AEH44560.1
KEGG: saf:SULAZ_1167 putative lipoprotein; SPTR: Putative lipoprotein; IMG reference gene:2505283976.
  
     0.671
bpsA
Protein of unknown function DUF43; Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.
  
     0.624
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
      
 0.618
AEH45513.1
Bacterio-opsin activator HTH domain protein; COGs: COG1318 transcriptional regulator protein; KEGG: abi:Aboo_0950 bacterio-opsin activator HTH domain protein; SPTR: Bacterio-opsin activator HTH domain protein; IMG reference gene:2505284976; TIGRFAM: probable regulatory domain.
  
     0.559
AEH44968.1
Putative circadian clock protein, KaiC; COGs: COG0467 RecA-superfamily ATPase implicated in signal transduction; InterPro IPR014774:IPR010624; KEGG: aae:aq_204 hypothetical protein; PFAM: Circadian clock protein KaiC central region; SPTR: Putative uncharacterized protein; IMG reference gene:2505284407; PFAM: KaiC; TIGRFAM: KaiC domain protein, AF_0795 family.
  
     0.555
rgy
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
  
     0.540
AEH45911.1
Methyl-accepting chemotaxis sensory transducer with Cache sensor; COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR013163:IPR004089:IPR000727:IPR003660; KEGG: tna:CTN_1065 methyl-accepting chemotaxis protein 4; PFAM: chemotaxis sensory transducer; Cache type 2 domain protein; SMART: chemotaxis sensory transducer; SPTR: Methyl-accepting chemotaxis protein 4; IMG reference gene:2505285398; PFAM: Cache domain; Methyl-accepting chemotaxis protein (MCP) signaling domain.
       0.489
AEH45893.1
Proto-chlorophyllide reductase 57 kD subunit; COGs: COG2221 Dissimilatory sulfite reductase (desulfoviridin) alpha and beta subunits; InterPro IPR017900:IPR013580:IPR006067:IPR017896; KEGG: dol:Dole_0748 proto-chlorophyllide reductase 57 kD subunit; PFAM: Proto-chlorophyllide reductase 57 kD subunit; nitrite and sulphite reductase 4Fe-4S region; SPTR: Proto-chlorophyllide reductase 57 kD subunit; IMG reference gene:2505285380; PFAM: 4Fe-4S binding domain; Nitrite and sulphite reductase 4Fe-4S domain; Proto-chlorophyllide reductase 57 kD subunit.
  
     0.485
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.