Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (233 aa)    
Predicted Functional Partners:
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
 
 0.998
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
 
 0.994
AEH44382.1
Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR007197:IPR005244:IPR006638; KEGG: pth:PTH_0983 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Biotin synthase and related enzymes; manually curated; IMG reference gene:2505283789; PFAM: Radical SAM superfamily; TIGRFAM: iron-only hydrogenase maturation rSAM protein HydE.
 
 
 0.980
AEH43913.1
8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839:IPR004723:IPR001917; KEGG: cch:Cag_0079 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: 8-amino-7-oxononanoate synthase; TIGRFAM: 8-amino-7-oxononanoate synthase; IMG reference gene:2505283309; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase.
 
  
 0.973
bioC
Methyltransferase type 11; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
 
  
 0.936
AEH45951.1
Protein of unknown function DUF452; COGs: COG2830 conserved hypothetical protein; InterPro IPR007398; KEGG: bfs:BF1615 putative biotin synthesis-related fusion protein; PFAM: protein of unknown function DUF452; SPTR: Putative uncharacterized protein; IMG reference gene:2505285440; PFAM: Protein of unknown function (DUF452).
 
    0.912
AEH45952.1
Aminoglycoside phosphotransferase; COGs: COG2187 conserved hypothetical protein; InterPro IPR002575; KEGG: tye:THEYE_A1962 Uma3; PFAM: aminoglycoside phosphotransferase; SPTR: Uma3; IMG reference gene:2505285441; PFAM: Chromatin associated protein KTI12.
       0.773
trpS
tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.746
AEH44803.1
COGs: COG0077 Prephenate dehydratase; InterProIPR018528:IPR020822:IPR001086:IPR002912:IPR 008242:IPR002701; KEGG: dak:DaAHT2_0619 prephenate dehydratase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; PRIAM: Prephenate dehydratase; SPTR: Prephenate dehydratase:Chorismate mutase:Amino acid-binding ACT; IMG reference gene:2505284236; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II.
     
 0.556
cobS
Cobalamin-5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
   
  
 0.529
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.