Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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trpFCOGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: tye:THEYE_A0943 N-(5'phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; IMG reference gene:2505285460; PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (213 aa)    
Predicted Functional Partners:
trpC
COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR001468:IPR013798; KEGG: dak:DaAHT2_0450 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol-phosphate synthase; manually curated; IMG reference gene:2505284432; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.999
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.997
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.997
AEH44721.1
Glutamine amidotransferase of anthranilate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR017926:IPR000991:IPR006220:IPR011702:IPR 001317:IPR006221; KEGG: dak:DaAHT2_0448 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; IMG reference gene:2505284146; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
  
 0.995
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 0.994
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
  
 0.910
AEH45515.1
COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterProIPR019999:IPR005802:IPR018300:IPR001202:IPR 015890:IPR001544; KEGG: dak:DaAHT2_0244 para-aminobenzoate synthase, subunit I; PFAM: Chorismate binding-like; aminotransferase class IV; SPTR: Para-aminobenzoate synthase, component I; TIGRFAM: para-aminobenzoate synthase, subunit I; IMG reference gene:2505284978; PFAM: Aminotransferase class IV; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade.
 
  
 0.871
AEH45972.1
COGs: COG2804 Type II secretory pathway ATPase PulE/Tfp pilus assembly pathway ATPase PilB; InterPro IPR001482:IPR007831:IPR003593; KEGG: dat:HRM2_30260 GspE3; PFAM: type II secretion system protein E; General secretory system II protein E domain protein; SMART: AAA ATPase; SPTR: GspE3; IMG reference gene:2505285461; PFAM: Type II/IV secretion system protein.
       0.773
AEH45973.1
General secretion pathway protein G; COGs: COG2165 Type II secretory pathway pseudopilin PulG; InterPro IPR000983:IPR012902:IPR013545:IPR010054; KEGG: tbd:Tbd_1293 tyep II secretion system protein G; PFAM: type II secretion system protein G; SPTR: Tyep II secretion system protein G; TIGRFAM: general secretion pathway protein G; IMG reference gene:2505285462; PFAM: Prokaryotic N-terminal methylation motif; Bacterial type II secretion system protein G; TIGRFAM: general secretion pathway protein G; prepilin-type N-terminal cleavage/methylation domain.
       0.773
AEH45974.1
Type II secretion system F domain protein; COGs: COG1459 Type II secretory pathway component PulF; InterPro IPR003004:IPR018076; KEGG: alv:Alvin_3015 type II secretion system F domain protein; PFAM: Type II secretion system F domain; SPTR: Type II secretion system F domain protein; IMG reference gene:2505285463; PFAM: Bacterial type II secretion system protein F domain.
       0.773
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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