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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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AEH46004.1Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (825 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 0.986
AEH45570.1
ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439:IPR017871; KEGG: tye:THEYE_A1038 excinuclease ABC, A subunit; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: Excinuclease ABC, A subunit; IMG reference gene:2505285037; PFAM: ABC transporter.
  
  
 
0.916
AEH44191.1
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
  
  
 
0.908
uvrC
Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 0.856
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
   
 
 0.707
AEH46008.1
ABC transporter related protein; COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003593:IPR003439:IPR013611:IPR017871; KEGG: ddf:DEFDS_1581 spermidine/putrescine ABC transporter ATP-binding protein; PFAM: ABC transporter related; Transport-associated OB domain-containing protein; SMART: AAA ATPase; SPTR: Spermidine/putrescine ABC transporter, ATP-binding protein (PotA); IMG reference gene:2505285497; PFAM: ABC transporter; TOBE domain.
     
 0.594
AEH46005.1
Type I phosphodiesterase/nucleotide pyrophosphatase; COGs: COG1524 Uncharacterized protein of the AP superfamily; InterPro IPR002591; KEGG: rca:Rcas_1244 type I phosphodiesterase/nucleotide pyrophosphatase; PFAM: type I phosphodiesterase/nucleotide pyrophosphatase; SPTR: Type I phosphodiesterase/nucleotide pyrophosphatase; IMG reference gene:2505285494; PFAM: Type I phosphodiesterase / nucleotide pyrophosphatase.
       0.588
AEH46006.1
Binding-protein-dependent transport systems inner membrane component; COGs: COG1177 ABC-type spermidine/putrescine transport system permease component II; InterPro IPR000515; KEGG: ddf:DEFDS_1579 spermidine/putrescine ABC transporter permease; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: ABC-type spermidine/putrescine transport system, permease component II; IMG reference gene:2505285495; PFAM: Binding-protein-dependent transport system inner membrane component.
       0.588
AEH46007.1
Binding-protein-dependent transport systems inner membrane component; COGs: COG1176 ABC-type spermidine/putrescine transport system permease component I; InterPro IPR000515; KEGG: ant:Arnit_1316 binding-protein-dependent transporter inner membrane component; PFAM: binding-protein-dependent transport systems inner membrane component; SPTR: ABC-type spermidine/putrescine transport system, permease component I; IMG reference gene:2505285496; PFAM: Binding-protein-dependent transport system inner membrane component.
       0.588
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.553
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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