close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (176 aa)    
Predicted Functional Partners:
AEH44458.1
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.727
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.655
AEH46019.1
Isochorismatase hydrolase; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: dak:DaAHT2_0562 isochorismatase hydrolase; PFAM: isochorismatase hydrolase; SPTR: Isochorismatase hydrolase; IMG reference gene:2505285508; PFAM: Isochorismatase family.
  
  
 0.587
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.579
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
 
   
 0.562
AEH46021.1
Rubredoxin-type Fe(Cys)4 protein; COGs: COG1773 Rubredoxin; InterPro IPR001052:IPR004039:IPR018527; KEGG: dak:DaAHT2_1019 rubredoxin-type Fe(Cys)4 protein; PFAM: Rubredoxin-type Fe(Cys)4 protein; SPTR: Rubredoxin; IMG reference gene:2505285510; PFAM: Rubredoxin.
       0.543
AEH46022.1
KEGG: dak:DaAHT2_2128 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285511.
       0.535
AEH44881.1
KEGG: aco:Amico_0065 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505284319.
    
   0.522
AEH45754.1
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; COGs: COG2242 Precorrin-6B methylase 2; InterProIPR006365:IPR000878:IPR003358:IPR012818:IPR 014008; KEGG: dal:Dalk_0449 precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; methyltransferase; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,1 [...]
      
 0.504
AEH44241.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.439
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.