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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH46032.1COGs: COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein); InterPro IPR019734:IPR003171:IPR016041:IPR013026; KEGG: dak:DaAHT2_0826 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; methylenetetrahydrofolate reductase; SPTR: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; IMG reference gene:2505285521; PFAM: Methylenetetrahydrofolate reductase; CO dehydrogenase/acetyl-CoA synthase delta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase, delta subunit. (892 aa)    
Predicted Functional Partners:
AEH46030.1
CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; COGs: COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein); InterPro IPR007202:IPR016041:IPR016218; KEGG: dak:DaAHT2_0824 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Fe-S cluster domain protein; SPTR: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; IMG reference gene:2505285519; PFAM: Putative Fe-S cluster; CO dehydrogenase/acetyl-CoA synthase delta subunit.
 
 0.999
AEH46031.1
COGs: COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit; InterPro IPR004461; KEGG: dak:DaAHT2_0825 CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; PRIAM: CO-methylating acetyl-CoA synthase; SPTR: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; IMG reference gene:2505285520; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; TIGRFAM: CO dehydrogenase/CO-methylating acetyl-CoA synthase complex, beta subunit.
  
 0.998
AEH45313.1
InterPro IPR007202; KEGG: dak:DaAHT2_0716 Fe-S cluster domain protein; PFAM: Fe-S cluster domain protein; SPTR: Putative Fe-S cluster; IMG reference gene:2505284768; PFAM: Putative Fe-S cluster.
 
 
 0.990
AEH46027.1
Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: dak:DaAHT2_1991 dihydropteroate synthase DhpS; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase DHPS; IMG reference gene:2505285516; PFAM: Pterin binding enzyme.
 
 
 0.985
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.980
fhs
Formate--tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR000559:IPR020628; KEGG: dak:DaAHT2_0837 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; IMG reference gene:2505285529; PFAM: Formate--tetrahydrofolate ligase.
 
 
 0.978
AEH46033.1
KEGG: pth:PTH_1005 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2505285522; PFAM: Methylene-tetrahydrofolate reductase C terminal.
 
  
 0.976
AEH45300.1
Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: dak:DaAHT2_1991 dihydropteroate synthase DhpS; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase DHPS; IMG reference gene:2505284753; PFAM: Pterin binding enzyme.
 
 
 0.974
AEH45468.1
COGs: COG0192 S-adenosylmethionine synthetase; InterPro IPR002133; KEGG: nmu:Nmul_A0036 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase; PRIAM: Methionine adenosyltransferase; SPTR: S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); TIGRFAM: S-adenosylmethionine synthetase; IMG reference gene:2505284930; PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet [...]
  
 
 0.956
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.956
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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