close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnDUTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (822 aa)    
Predicted Functional Partners:
AEH46046.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002187:IPR002332:IPR017918; KEGG: pmx:PERMA_1585 nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Nitrogen regulatory protein P-II; IMG reference gene:2505285535; PFAM: Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.993
AEH44088.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR002187:IPR017918; KEGG: dth:DICTH_0174 nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Nitrogen regulatory protein P-II; IMG reference gene:2505283486; PFAM: Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.962
AEH46044.1
COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: dal:Dalk_5100 glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; SPTR: Glutamine synthetase; TIGRFAM: glutamine synthetase, type I; IMG reference gene:2505285533; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
 
   
 0.840
AEH44946.1
(Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...]
 
   
 0.778
AEH44921.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR017918:IPR002187; KEGG: mfs:MFS40622_0032 nitrogen regulatory protein P-II; PFAM: nitrogen regulatory protein P-II; SPTR: Nitrogen regulatory protein P-II; IMG reference gene:2505284360; PFAM: Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.612
AEH44922.1
COGs: COG0347 Nitrogen regulatory protein PII; InterPro IPR017918:IPR002187; KEGG: mba:Mbar_A2279 P-II family nitrogen regulatory protein; PFAM: nitrogen regulatory protein P-II; SPTR: Nitrogen regulatory protein P-II; IMG reference gene:2505284361; PFAM: Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.606
AEH46043.1
Methyltransferase type 11; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216; KEGG: sul:SYO3AOP1_1193 methyltransferase type 11; PFAM: Methyltransferase type 11; SPTR: Methyltransferase type 11; IMG reference gene:2505285532; PFAM: Methyltransferase domain.
       0.519
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
       0.474
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
     
 0.473
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.460
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.