close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (418 aa)    
Predicted Functional Partners:
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
 
 
 0.930
AEH46032.1
COGs: COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein); InterPro IPR019734:IPR003171:IPR016041:IPR013026; KEGG: dak:DaAHT2_0826 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; methylenetetrahydrofolate reductase; SPTR: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; IMG reference gene:2505285521; PFAM: Methylenetetrahydrofolate reductase; CO dehydrogenase/acetyl-CoA synthase delta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase, delta subunit.
  
 
 0.921
AEH44415.1
NIL domain protein; InterPro IPR018449:IPR017896:IPR017900; KEGG: sat:SYN_00800 ferridoxin; PFAM: NIL domain; SPTR: Ferridoxin; IMG reference gene:2505283827; PFAM: 4Fe-4S binding domain; NIL domain.
     
  0.900
AEH45222.1
Protein of unknown function DUF39; COGs: COG1900 conserved hypothetical protein; InterPro IPR002708; KEGG: dal:Dalk_1368 protein of unknown function DUF39; PFAM: protein of unknown function DUF39; SPTR: Putative uncharacterized protein; IMG reference gene:2505284669; PFAM: Domain of unknown function DUF39.
     
  0.900
AEH44500.1
COGs: COG0460 Homoserine dehydrogenase; InterProIPR016204:IPR005106:IPR001342:IPR002912:IPR 019811; KEGG: sfu:Sfum_1218 homoserine dehydrogenase; PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; SPTR: Homoserine dehydrogenase; IMG reference gene:2505283914; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain.
   
 
  0.813
AEH46047.1
InterPro IPR005358; KEGG: dak:DaAHT2_0703 protein of unknown function UPF0153; PFAM: protein of unknown function UPF0153; SPTR: Putative uncharacterized protein; IMG reference gene:2505285536; PFAM: Uncharacterised protein family (UPF0153).
       0.791
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
       0.791
AEH46051.1
Hypothetical protein; COGs: COG2248 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR014426; KEGG: afu:AF0504 hypothetical protein; SPTR: UPF0282 protein AF_0504; IMG reference gene:2505285540; PFAM: Metallo-beta-lactamase superfamily.
       0.729
AEH45468.1
COGs: COG0192 S-adenosylmethionine synthetase; InterPro IPR002133; KEGG: nmu:Nmul_A0036 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase; PRIAM: Methionine adenosyltransferase; SPTR: S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT); TIGRFAM: S-adenosylmethionine synthetase; IMG reference gene:2505284930; PFAM: S-adenosylmethionine synthetase, C-terminal domain; S-adenosylmethionine synthetase, central domain; S-adenosylmethionine synthetase, N-terminal domain; TIGRFAM: S-adenosylmethionine synthetase; Belongs to the AdoMet [...]
 
 
 0.723
AEH43905.1
Methionine synthase vitamin-B12 independent; InterPro IPR002629; KEGG: dat:HRM2_37800 hypothetical protein; PFAM: Methionine synthase vitamin-B12 independent; SPTR: Putative uncharacterized protein; IMG reference gene:2505283300; PFAM: Cobalamin-independent synthase, Catalytic domain.
  
  
 0.713
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.