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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEH46051.1Hypothetical protein; COGs: COG2248 hydrolase (metallo-beta-lactamase superfamily); InterPro IPR014426; KEGG: afu:AF0504 hypothetical protein; SPTR: UPF0282 protein AF_0504; IMG reference gene:2505285540; PFAM: Metallo-beta-lactamase superfamily. (295 aa)    
Predicted Functional Partners:
AEH45499.1
Protein of unknown function DUF72; COGs: COG1801 conserved hypothetical protein; InterPro IPR002763; KEGG: pho:PH0152 hypothetical protein; PFAM: protein of unknown function DUF72; SPTR: Putative uncharacterized protein PH0152; IMG reference gene:2505284961; PFAM: Protein of unknown function DUF72.
  
     0.773
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
       0.747
AEH46047.1
InterPro IPR005358; KEGG: dak:DaAHT2_0703 protein of unknown function UPF0153; PFAM: protein of unknown function UPF0153; SPTR: Putative uncharacterized protein; IMG reference gene:2505285536; PFAM: Uncharacterised protein family (UPF0153).
       0.729
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
       0.729
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
       0.729
rgy
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
  
     0.707
AEH45698.1
Peptidase zinc-dependent; COGs: COG1913 Zn-dependent protease; InterPro IPR012091:IPR012962; KEGG: dth:DICTH_1693 hypothetical protein; PFAM: peptidase zinc-dependent; SPTR: Putative uncharacterized protein; IMG reference gene:2505285169; PFAM: Peptidase family M54.
  
     0.589
AEH45749.1
Glycosyltransferase 28 domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR007235; KEGG: mif:Metin_0813 SMC domain protein; PFAM: Glycosyltransferase 28 domain; SPTR: DNA double-strand break repair Rad50 ATPase; IMG reference gene:2505285225.
  
     0.567
AEH45408.1
Protein of unknown function DUF763; COGs: COG1415 conserved hypothetical protein; InterPro IPR008482; KEGG: mta:Moth_0136 hypothetical protein; PFAM: protein of unknown function DUF763; SPTR: Putative uncharacterized protein; IMG reference gene:2505284866; PFAM: Protein of unknown function (DUF763).
  
     0.546
AEH44496.1
Radical SAM domain protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR016431:IPR007197; KEGG: mtp:Mthe_1490 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: Radical SAM domain protein; IMG reference gene:2505283910; PFAM: Radical SAM superfamily.
  
     0.447
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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