Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEH46058.1UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: pmo:Pmob_0383 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: UBA/THIF-type NAD/FAD binding protein; IMG reference gene:2505285549; PFAM: MoeZ/MoeB domain; ThiF family. (222 aa)    
Predicted Functional Partners:
AEH46059.1
MoaD family protein; InterPro IPR003749:IPR010038; KEGG: pmo:Pmob_0384 MoaD family protein; PFAM: thiamineS protein; SPTR: MoaD family protein; TIGRFAM: MoaD family protein; IMG reference gene:2505285550; PFAM: ThiS family; TIGRFAM: MoaD family protein, archaeal.
  
 0.989
AEH44753.1
COGs: COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase; InterPro IPR016454:IPR000192:IPR020578; KEGG: geo:Geob_2507 aminotransferase class V; PFAM: aminotransferase class V; PRIAM: Cysteine desulfurase; SPTR: Aminotransferase class V; IMG reference gene:2505284180; PFAM: Aminotransferase class-V.
   
 0.934
AEH45561.1
Molybdopterin biosynthesis MoaE protein; InterPro IPR003448; KEGG: tye:THEYE_A0839 molybdopterin converting factor, subunit 2; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: Protein involved in biosynthesis of molybdopterin; IMG reference gene:2505285026; PFAM: MoaE protein.
  
 0.661
AEH45727.1
Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
 
  
 0.614
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.612
AEH44406.1
Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399:IPR013749:IPR019293; KEGG: pho:PH1155 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; Phosphomethylpyrimidine kinase; PRIAM: Phosphomethylpyrimidine kinase; SPTR: 446aa long hypothetical thiamine biosynthesis protein; TIGRFAM: phosphomethylpyrimidine kinase; IMG reference gene:2505283818; PFAM: Phosphomethylpyrimidine kinase; Archaeal phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
 
  
 0.598
AEH45708.1
Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
 
  
 0.591
AEH46062.1
Dihydrouridine synthase DuS; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.
 
     0.571
AEH46060.1
Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176:IPR004839:IPR004838; KEGG: dak:DaAHT2_0099 aminotransferase class I and II; PFAM: aminotransferase class I and II; SPTR: Aminotransferase class I and II; IMG reference gene:2505285551; PFAM: Aminotransferase class I and II.
  
    0.565
AEH46063.1
COGs: COG1639 signal transduction protein; InterPro IPR013976; KEGG: slt:Slit_2006 serine/threonine protein kinase; PFAM: Metal-dependent hydrolase HDOD; SPTR: Serine/threonine protein kinase; IMG reference gene:2505285554; PFAM: HDOD domain.
 
     0.563
Your Current Organism:
Thermodesulfatator indicus
NCBI taxonomy Id: 667014
Other names: T. indicus DSM 15286, Thermodesulfatator indicus CIR29812, Thermodesulfatator indicus DSM 15286, Thermodesulfatator indicus str. DSM 15286, Thermodesulfatator indicus strain DSM 15286, Thermodesulfobacterium sp. CIR29812
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